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FLASH GENE
Symbol KTN1 contributors: mct - updated : 11-10-2023
HGNC name kinectin 1 (kinesin receptor)
HGNC id 6467
DNA
TYPE functioning gene
STRUCTURE 104.38 kb     43 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
44 - 5507 - 1329 - 1995 7787243
43 - 5420 - 1300 - 1995 7787243
44 - 4771 - 1330 - 1995 7787243
45 - 4852 - 1357 - 1995 7787243
44 - 4681 - 1300 - 1995 7787243
41 - 4768 - 1329 - 1995 7787243
43 - 4699 - 1306 - 1995 7787243
42 - 4591 - 1270 - 1995 7787243
44 - 4765 - 1328 - 1995 7787243
43 - 4215 - 1145 - 1995 7787243
42 - 4612 - 1277 - 1995 7787243
44 - 4728 - 1357 - 1995 7787243
43 - 4212 - 1144 - 1995 7787243
43 - 4644 - 1329 - 1995 7787243
44 - 4761 - 1328 - 1995 7787243
38 - 4554 - 1299 - 1995 7787243
43 - 4641 - 1328 - 1995 7787243
42 - 4557 - 1300 - 1995 7787243
42 - 4551 - 1298 - 1995 7787243
41 - 4467 - 1270 - 1995 7787243
43 - 4659 - 1334 - 1995 7787243
42 - 4575 - 1306 - 1995 7787243
42 - 4572 - 1305 - 1995 7787243
41 - 4488 - 1277 - 1995 7787243
42 - 4575 - 1306 - 1995 7787243
41 - 4004 - 1116 - 1995 7787243
43 - 4175 - 1173 - 1995 7787243
42 - 4091 - 1145 - 1995 7787243
40 - 3914 - 1086 - 1995 7787243
41 - 4022 - 1122 - 1995 7787243
40 - 3935 - 1093 - 1995 7787243
39 - 3651 - 968 - 1995 7787243
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Endocrineneuroendocrinepituitary  highly
Nervousbrainbasal nucleiputamen highly Homo sapiens
Reproductivefemale systemovary   
Urinarybladder   highly
 kidney   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear localization signal (NLS)
  • interspersed heptad repeats
  • residues 7-29 of kinectin are sufficient for targeting to the ER membrane but insufficient for remaining on the ER
  • HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, iKAPPAb kinase subfamily
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • large integral ER membrane protein, phosphorylating inhibitors of NF-kappa-b thus leading to the dissociation of the inhibitor/NF-kappa-b complex and ultimately the degradation of the inhibitor
  • KTN1-mediated endoplasmic reticulum dynamics supports focal adhesion growth in the cellular lamella
  • receptor for kinesin involved in kinesin-driven vesicle
  • KTN1 may play a functional role in the development of ADHD
  • promotes the occurrence and deterioration of HCC by mediating cell survival, migration, invasion, cell cycle activation, and apoptotic inhibition
  • KTN1 preferentially binds perinuclear polyglutamylated microtubules with long glutamate chains
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with mavs/IPS1
  • RAB18 regulates likely KTN1 transport toward the cell surface to form ER-FA contacts, thus promoting focal adhesions (FAs) growth and cell migration during chemotaxis
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly correlated with poorer prognosis of Hepatocellular carcinoma (HCC) patients
    tumoral     --over  
    in breast cancer, and Triple-negative breast cancer (TNBC) patients with high KTN1 expression have poor prognosis
    Susceptibility to attention deficit hyperactivity disorder (ADHD)
    Variant & Polymorphism other
  • KTN1 variants were significantly associated with ADHD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    may be a therapeutic target in HCC patients
    cancerreproductivebreast
    KTN1 may be a potential molecular target for the development of TNBC treatment
    ANIMAL & CELL MODELS