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FLASH GENE
Symbol PPP2R3A contributors: npt/ - updated : 16-01-2006
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha
HGNC id 9307
DNA
TYPE functioning gene
STRUCTURE 182.17 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing polyA site 5200 130.3 1150 heart, brain, placenta, lung, skeletal muscle, kidney lowly Hendrix
- splicing polyA site 2800 72 529 heart, skeletal muscle highly Hendrix
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • stretches of basic residues that may be putative nuclear localization signals (NLS)
  • a cluster of proline residues in an N terminal region common to both isoforms
  • HOMOLOGY
    interspecies ortholog to murine Ppp2r3
    homolog to C.elegans F56h9.5
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular subcellular compartment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • regulatory subunit of protein phosphatase 2a consisting of a common heterodimeric core enzyme composed of a 36 kDa catalytic subunit (subunit c) and a 65 kDa constant regulatory subunit (pr65 or subunit a) and associating with a variety of regulatory subunits (including three families of subunits b..)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS