SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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| in the primary cilium of tubular epithelial cells |
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localized at a distinctive proximal segment of the primary cilium |
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basic FUNCTION
| involved in the left-right body axis and in regulating the cell cycle |
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may be functioning in renal tubular development and function |
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acting as a molecular switch between different Wnt signaling cascades |
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acts as a molecular anchor for NPHP3 and NEK8 in the proximal segment of primary cilia |
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inhibiting the canonical Wnt pathway by targeting cytoplasmic dishevelled (Dsh or Dvl1) for degradation (essential for normal renal cell development) |
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Required for tubule elongation, and for normal pronephros development |
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regulates Wnt signaling and is required for convergent extension movements during early embryogenesis |
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acts downstream of Frizzled-8 in pronephros morphogenesis |
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may plays a role in noncanonical Wnt signaling in the kidney |
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essential for the morphogenesis of the proximal and intermediate pronephric system and relays Frizzled-8–dependent signals to recruit Dishevelled to the plasma membrane |
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B9D2, INVS, and IQCB1 support the transport of a cargo protein, Opsin, but not another photoreceptor ciliary transmembrane protein, Peripherin (PHPN) |
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Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos |
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is involved in the control of ciliary disassembly |
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played an important role in embryonic development and renal diseases |
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might promote the tumorigenicity of lung cancer cells |