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FLASH GENE
Symbol GGA1 contributors: mct/npt/pgu - updated : 19-04-2015
HGNC name golgi associated, gamma adaptin ear containing, ARF binding protein 1
HGNC id 17842
DNA
TYPE functioning gene
STRUCTURE 25.07 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2924 - 552 - 2007 17596511
3 - 1714 9.84 89 - 2007 17596511
17 - 3185 70.25 639 - 2007 17596511
- - 3173 - 635 - 2007 17596511
- - 3231 - 566 - 2007 17596511
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one N-terminal VHS/GAT domain, interacting with both ARF and Rabaptin-5(RABEP1)
  • C-terminal three-helix bundle motif of the GAT domain is directly involved in RABEP1 binding
  • one or two coiled-coil domain
  • one C terminal region with homology to the car domain of gamma adaptins (adaptin domain)
  • secondary structure right handed superhelix with eight alpha helices
    HOMOLOGY
    Homologene
    FAMILY
  • ADP-ribosylation factor binding protein family
  • GGA protein family
  • CATEGORY adaptor , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text trans-golgi network
    basic FUNCTION
  • involved in the regulation of membrane traffic through the trans-Golgi network to endosomes/lysosomes
  • sorting MGP receptors and lysosome enzymes
  • implicated in the sorting of mannose 6-phosphate receptor (MPR)
  • monomeric clathrin adaptors that mediate cargo sorting and vesicle formation at the TGN
  • conserved role for GGA1, GGA2, GGA3 proteins in regulating phosphatidylinositol 4-kinase function at the TGN
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , endocytosis transport , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • complexing through the VHS domain with the cytoplasmic domains of sorting receptors such as the mannose phosphate receptor by recognizing the acidic cluster dileucine (ACLL) sequences
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting by its VHS domain with the cytoplasmic tail of sortilin SORT1
  • binding BACE
  • associated with Golgi membranes through interaction between their GGAH domains and ADP-ribosylation factors
  • phosphorylated by casein kinase 2 (CSNK2A1)
  • direct interaction of AP1AR with gamma1-adaptin (GGA1), that is crucial for membrane association and thus the function of the AP-1 complex in living cells
  • interaction between GGA1, GGA2, GGA3 and RABEP1 is likely to take place in a pathway between the trans-Golgi network and early endosomes
  • bind PI4P primarily through their GAT domain, in a region called C-GAT that also binds ubiquitin
  • MON2 directly interacts with GGA1, GGA2, GGA3 through the VHS domain
  • interacting with the adaptor-related protein complex AP.1
  • interacting with CNST
  • PI4KB interacted preferentially with the VHS domain of GGA2 compared with VHS domains of GGA1 and GGA3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS