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FLASH GENE
Symbol CAMSAP3 contributors: mct/npt - updated : 30-08-2018
HGNC name calmodulin regulated spectrin associated protein family member 3
HGNC id 29307
DNA
TYPE functioning gene
STRUCTURE 22.41 kb     19 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 - 4201 - 1276 - 2017 28089391
17 - 4120 135 1249 - 2017 28089391
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   highly
Endocrinepancreas   highly
Hearing/EquilibriumearinnercochleaCorti  Homo sapiens
Nervousbrainbasal nucleicorpus callosum  
 braindiencephalonthalamus highly
 braindiencephalonhypothalamus highly
 brainbasal nucleicaudate nucleus highly
 brainhindbraincerebellum highly
 braindiencephalonamygdala highly
 spinal cord   lowly
Reproductivefemale systemovary  highly
 male systemtestis  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text highly in brain and liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal calponin homology domain
  • two central coiled-coil regions (CC1 and 2), and CC1 domain of CAMSAP3 is crucial for its apical localization
  • a C-terminal DUF1781 domain of unknown function
  • secondary structure
  • a short helical motif conserved in CAMSAP2 and CAMSAP3 binds to the heterodimer formed by the N- and C-terminal domains of katanin subunits p60 and p80, respectively
  • HOMOLOGY
    Homologene
    FAMILY
  • CAMSAP/Patronin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • localized with PLEKHA7 along the zonula adherens (Meng 2008)
  • localizes at Noncentrosomal microtubules Minus Ends (Meng 2008)
  • non-centrosomal MT minus-end protein, accumulating in the pericentrosomal area and accompanies the release of MTs from the centrosome
  • basic FUNCTION
  • PLEKHA7/NEZHA complex regulates the zonula adherens integrity by recruiting KIFC3 to this junctional site (Meng 2008)
  • CAMSAP3 and its related protein, CAMSAP2, cooperate in organization of noncentrosomal microtubules
  • CAMSAP2 and -3 work together to maintain noncentrosomal microtubules, suppressing the microtubule-organizing ability of the centrosome, and that the network of CAMSAP-anchored microtubules is important for proper organelle assembly
  • members of the CAMSAP/Patronin family all localize to and protect minus-ends but have evolved distinct effects on MT dynamics
  • apically localized CAMSAP3 determines the proper orientation of microtubules, and in turn that of organelles, in mature mammalian epithelial cells
  • CAMSAP1, CAMSAP2, CAMSAP3 act to polarise microtubules (MT) along the apical-basal axis to enable apical transport of RAB11A endosomes
  • plays a role in translocation of Golgi vesicles in epithelial cells
  • is a key molecule for generation of non-centrosomal MTs
  • CAMSAP2 and CAMSAP3 bind to growing microtubule minus ends, where they form stretches of stabilized microtubule lattice
  • WDR47, CAMSAP1, CAMSAP2, CAMSAP3, and Katanin function together for the generation of non-centrosomal microtubule arrays in polarized subcellular compartments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • partner of PLEKHA7 (Meng 2008)
  • cooperates with KIFC3 for the maintenance of the zonula adherens (Meng 2008)
  • CAMSAP3-anchored non-centrosomal microtubules capture ARHGEF2 more efficiently than other microtubules do and a balance between these microtubules is important to maintain proper actin organization
  • interaction between CDH23 and CAMSAP3/Marshalin plays a vital role in hearing and vision, suggesting that CDH23-C is a CAMSAP3/Marshalin-binding protein that can modify MT networks indirectly through its interaction with CAMSAP3/Marshalin
  • MACF1 specifically binds to CAMSAP3 and is required for the apical localization of CAMSAP3-decorated microtubule minus ends
  • WDR47 facilitates proper neurite remodeling through CAMSAP1, CAMSAP2, CAMSAP3 to fine-tune regional microtubule dynamics and organization during early stages of neuronal polarization
  • cell & other
  • bound microtubules at their minus ends and tethered them to the zonula adherens (Meng 2008)
  • CAMSAP1, CAMSAP2, CAMSAP3 bind specifically to MT minus-ends and protect them against kinesin-13-induced depolymerization
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS