basic FUNCTION
| PLEKHA7/NEZHA complex regulates the zonula adherens integrity by recruiting KIFC3 to this junctional site (Meng 2008) |
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CAMSAP3 and its related protein, CAMSAP2, cooperate in organization of noncentrosomal microtubules |
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CAMSAP2 and -3 work together to maintain noncentrosomal microtubules, suppressing the microtubule-organizing ability of the centrosome, and that the network of CAMSAP-anchored microtubules is important for proper organelle assembly |
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members of the CAMSAP/Patronin family all localize to and protect minus-ends but have evolved distinct effects on MT dynamics |
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apically localized CAMSAP3 determines the proper orientation of microtubules, and in turn that of organelles, in mature mammalian epithelial cells |
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CAMSAP1, CAMSAP2, CAMSAP3 act to polarise microtubules (MT) along the apical-basal axis to enable apical transport of RAB11A endosomes |
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plays a role in translocation of Golgi vesicles in epithelial cells |
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is a key molecule for generation of non-centrosomal MTs |
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CAMSAP2 and CAMSAP3 bind to growing microtubule minus ends, where they form stretches of stabilized microtubule lattice |
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WDR47, CAMSAP1, CAMSAP2, CAMSAP3, and Katanin function together for the generation of non-centrosomal microtubule arrays in polarized subcellular compartments |