basic FUNCTION
| putative GTPase activator protein of RAB-like small GTPase |
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may act as a GTPase activating protein for RAB family protein |
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RabGAP (Rab GTPase-activating protein) that is a direct substrate of Akt and plays an essential role in the regulation of SLC2A4 trafficking, through the association with 14-3-3 proteins |
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key player in insulin signaling in skeletal muscle and adipose tissue, but is also a major effector of protein kinase B/Akt signaling in the beta-cell |
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Rab-GTPase activating protein implicated in insulin-stimulated glucose transporter 4 (GLUT4) translocation in adipocytes and myotubes |
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TBC1D1 and TBC1D4 are Rab GTPase-activating proteins (RabGAPs) in skeletal myocytes and adipocytes, respectively, with functions in SLC2A4 vesicle trafficking |
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protein involved in insulin-stimulated glucose transport in adipocytes |
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may control distinct Rab GTPases |
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central player in the surface expression levels of SLC2A4, SLC2A1, and epithelial sodium channel |
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regulates SLC2A4 trafficking in adipocytes |
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potentially acting as a regulatory switch in the docking and/or fusion of SLC2A4-containing storage vesicles with the plasma membrane |
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TBC1D4 (AS160) controls trafficking of the glucose transporter SLC2A4 in adipocytes and skeletal muscle cells |