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FLASH GENE
Symbol DHX38 contributors: mct - updated : 10-09-2019
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 38
HGNC id 17211
DNA
TYPE functioning gene
STRUCTURE 19.25 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 4323 140.4 1227 - 2018 30208423
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Nervousbrain    
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • a C terminal RNA helicase domain
  • helicase associated domain
  • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae Prp16
    Homologene
    FAMILY
  • DEAD/H box family of splicing factors
  • DEAH subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • pre-mRNA splicing factor, essential for the catalytic step 2 in pre-mRNA splicing process
  • DHX39 has dual roles in remodeling of the spliceosome in catalytic steps
  • DHX38 has likely a role in mitotic regulation as a component of the satellite I ncRNP complex at interphase
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the spliceosome
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • deletion of ISY1 favors the premature release of DHX38, thus promoting second-step chemistry of precursors with inappropriate 3prime-splice sites
  • ISY1 interacts with the ATPase DHX38 to regulate the fidelity of pre-mRNA splicing
  • during step 1 of splicing, PRPF8 interactions with SF3b proteins are replaced by SLU7, positioning this second step factor close to the active site, and that the DEAH-box helicases DHX16 and DHX38 cooperate through ordered interactions with GPKOW (PMIDl:
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RP84
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS