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FLASH GENE
Symbol TLE2 contributors: npt/SGE - updated : 27-07-2010
HGNC name transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
HGNC id 11838
DNA
TYPE functioning gene
STRUCTURE 50.00 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 2508 - 706 - Liu (1996)
18 - 2299 - 621 - Liu (1996)
20 - 2722 - 743 - Liu (1996)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunespleen   highly
Nervousbrain   moderately
Reproductivefemale systembreastmammary gland highly
 male systemprostate  highly
Respiratorylung   highly
Urinarykidney   moderately
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage immature epithelial cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • casein kinase II site/nuclear localization sequence motif with a pleckstrin homology (PH) domain
  • six WD repeats (Trp-Asp domains)
  • conjugated PhosphoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila split Groucho (Notch signaling pathway)
    homolog to murine Tle2 (92.0pc)
    homolog to rattus Tle2 (91.6pc)
    Homologene
    FAMILY
  • GROUCHO/TLE family of WD-repeat proteins
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibiting the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling
  • implicating these molecules in the maintenance of the undifferentiated state in epithelial cells (coexpressed with NOTCH)
  • transcrptional corepressor that binds to a number of transcription factors
  • inhibiting replication and transactivation mediated by RTA, providing another potentially important mechanism for maintenance of Kaposi's sarcoma-associated herpesvirus viral latency through interaction with a host protein (He 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • histogenesis and organogenesis
  • transcriptional corepressor
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homo-oligomer and hetero-oligomer with other family members
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to a number of transcription factors
  • binding to LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5
  • cell & other
    REGULATION
    Other the effects of full-length TLE family members may be modulated by association with dominant-negative AES
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    elevated expression in cervical squamous metaplasias and carcinomas (Liu 1996)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS