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FLASH GENE
Symbol RGS7 contributors: mct - updated : 09-03-2016
HGNC name regulator of G-protein signaling 7
HGNC id 10003
DNA
TYPE functioning gene
STRUCTURE 581.72 kb     18 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 2440 56.6 487 - -
16 - 2363 - 424 - -
17 - 2441 - 469 - -
18 - 2522 - 477 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Respiratorylung   moderately
Visualeyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Visualbipolar cell Homo sapiens
Visualcone photoreceptor
Visualrod photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RGS domain
  • a GGL (G protein gamma subunit-like)domain, that recruits G beta(5)
  • a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP , and punctate localization was mediated by the DEP/DHEX domains, and centrosomal localization was dependent on the DHEX domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Rgs7
    intraspecies homolog to EGLIO
    Homologene
    FAMILY
  • regulator of G protein family
  • subfamily R7
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • RGS7-GNB5 complex shuttled between plasma membrane and nucleus through RGS7BP binding
  • concentrated at the plasma membrane of cell bodies, in structures resembling lamellipodia or filopodia along the processes, and at the dendritic tips
  • had both diffuse cytosolic and punctate localization patterns and also localized in centrosomes
  • basic FUNCTION
  • crucial regulator of G-protein-coupled receptor signaling in the visual and nervous systems
  • RGS7, RGS11, and their binding partner GNB5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), and act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways
  • RGS7 and RGS11 act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways
  • RGS7 and RGS11 are the key GTPase accelerating proteins (GAPs) in the GRM6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses
  • action of RGS7 and RGS11 is required for the generation of rod ON-BC light responses with high sensitivity and speed
  • GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1
  • RGS7, in cooperation with its binding partner RGS7BP, regulates GABABR-GIRK signaling in hippocampal pyramidal neurons
  • is a novel regulator of mu-opioid receptor (MOR) signaling by dissecting its circuit specific actions and pinpointing its role in regulating morphine reward by controlling the activity of nucleus accumbens neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text promoting chondrocyte differentiation
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with GNB5 and forming an herterotrimer with the adition of RGS7BP
  • could form a homo-oligomer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDCL seems to stabilize the interaction of GNB5 with TCP1 until GNB5 is folded, after which it is released to allow GNB5 to interact with RGS7
  • role of GNB5 in the retina, and likely in the entire nervous system, mediated exclusively by RGS7 proteins
  • GPR179, is required for DBC function and recruits the regulators of G-protein signaling (RGS) proteins, RGS7 and RGS11, to the dendritic tips of the depolarizing bipolar cells (DBCs)
  • GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
  • GPR158 could bind to the RGS7 homo-oligomer without causing its dissociation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • RGS7(-/-) mouse is viable and fertile but smaller in body size