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FLASH GENE
Symbol LEPROTL1 contributors: mct/npt - updated : 21-10-2014
HGNC name leptin receptor overlapping transcript-like 1
HGNC id 6555
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping, gene in gene
STRUCTURE 42.30 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2721 14.4 131 - 2001 11342119
4 - 821 - 169 - 2001 11342119
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • JAK binding site (Pro (46)-Ile-Pro(48) preceded by a cluster of hydropobic residues)
  • four potential transmembrane domains
  • HOMOLOGY
    intraspecies homolog to LEPR
    Homologene
    FAMILY
  • OB-RGRP/VPS55 family
  • tetraspanning membrane proteins family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • with LEPROT influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism (Touvier 2009)
  • LEPROT and LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF21 prevents the GH effects on chondrocytes by activating LEPROT and LEPROTL1
  • FGF21 specifically and directly modulate LEPROT/LEPROTL1 expression and function in chondrocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS