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FLASH GENE
Symbol PCBP2 contributors: mct - updated : 03-01-2014
HGNC name poly(rC) binding protein 2
HGNC id 8648
DNA
TYPE functioning gene
STRUCTURE 29.06 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text many transcripts resulting from alternative splicing pathways (Makeyev)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 splicing 3187 - 366 - 1996 8833161
alternative acceptor site exon 8
15 splicing 3175 - 362 - 1996 8833161
lacking exon 8a
14 splicing 3082 - 331 - 1996 8833161
lacking exon 9
15 splicing 3184 - 365 - 1996 8833161
lacking 10a
15 splicing 3172 - 361 - 1996 8833161
alternative acceptor site at 5' end of exon 11
13 - 3043 - 318 - 1996 8833161
14 - 3094 - 335 - 1996 8833161
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Endocrineneuroendocrinepituitary  highly
Reproductivefemale systemuteruscervix highly
 male systemtestis   
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three K homology (KH) motifs, playing an important role in the regulation of translation of eukaryotic mRNA
  • HOMOLOGY
    interspecies homolog to murine Pcbp2
    intraspecies paralog to PCBP1
    paralog to PCBP3
    paralog to PCBP4
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • functioning as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure
  • implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA
  • implicated in control of RNA stability and translation and selective cap-independent transcription
  • playing a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability
  • involved in the selective expression of cell survival factors through posttranslational events
  • with CNBP, stimulate translation of the ornithine decarboxylase (ODC) internal ribosomal entry site (Gerbasi 2007)
  • appeared to function as part of a larger holo-ITAF ribonucleoprotein complex (Gerbasi 2007)
  • may play an important role in the IFNA response against HCV (hepatitis C virus) and may benefit the HCV clinical therapy
  • broad role for PCBP1 and PCBP2 in delivering iron to cytosolic nonheme iron enzymes
  • a feedback inhibitor of mitochondrial antiviral signaling that facilitates its degradation after viral infection
  • PCBP1 and PCBP2 may serve as iron chaperones to multiple classes of cytosolic nonheme iron enzymes and may have a particular role in restoring metal cofactors that are spontaneously lost in iron deficient cells
  • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • binding to BCR-ABL
  • binding partner of MAPKAP1
  • induced after viral infection, and its interaction with MAVS led to proteasomal degradation of MAVS (is recruited the HECT domain-containing E3 ligase ITCH to polyubiquitinate and degrade MAVS
  • negative regulator in MAVS-mediated signaling
  • SRSF4 binds to the proximal downstream intron of MAPT exon 10 at the FTDP-17 hotspot region and interacts with RBMX and PCBP2 (increased exon 10 inclusion in FTDP mutants may arise from weakened SRSF4 binding)
  • associated with DICER and promotes the processing of miRNA precursors (Cytosolic iron could modulate this association, as well as the multimerization of PCBP2 and its ability to bind to miRNA precursors, which can alter the processing of miRNA precursors)
  • PCBP1 and PCBP2 deliver iron to deoxyhypusine hydroxylase (DOHH), the dinuclear iron enzyme required for hypusine modification of the translation factor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    abrogated cellular responses to viral infection, whereas knockdown of PCBP2 exerted the opposite effect
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS