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FLASH GENE

Symbol

RAB4B

contributors: SGE/npt - updated : 06-04-2010

HGNC name	RAB4B, member RAS oncogene family
HGNC id	9782

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	18.68 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016154 8 - 1160 NP_057238 - 213 - He (2002)

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       lowly Digestive intestine large intestine colon   lowly   intestine small intestine     lowly   pancreas exocrine       moderately Lymphoid/Immune lymph node       highly   spleen       lowly   thymus       highly Reproductive female system ovary     highly   female system breast mammary gland   predominantly   male system prostate     highly   male system testis     lowly Respiratory lung       lowly Urinary kidney       lowly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     moderately

cells

System Cell Pubmed Species Stage Rna symbol not specific adipocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

Rab F motifs and Rab SF regions

conjugated

LipoP

HOMOLOGY

interspecies	homolog to rattus Rab4b (99.5 pc)
	homolog to murine Rab4b (99.5 pc)
	homolog to Drosophila Rab4 (75 pc)

Homologene

FAMILY	small GTPase superfamily
	Rab family
	RAS oncogene family

CATEGORY

regulatory , protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane
text	lipid-anchor to the cytoplasmic side of the cell membrane

basic FUNCTION	regulating vesicular trafficking pathways
	important player in the control of SLC2A4 trafficking in adipocytes (difference in its expression in obese diabetic states could act as a compensatory effect to minimize the glucose transport defect in their adipocytes) (Kaddai 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	vesicular trafficking

PATHWAY

metabolism

signaling

a component

prenylated, methylated

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

cell & other

REGULATION

induced by

the same regulatory machinery known to be essential for the expression of MHC class II genes

Other

regulated by a typical MHC class II-like enhancer

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Kawasaki disease

Variant & Polymorphism SNP	rs2233152 near MIA and RAB4B highly associated to Kawasaki disease

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS