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FLASH GENE
Symbol ACBD3 contributors: - updated : 01-09-2007
HGNC name acyl-Coenzyme A binding domain containing 3
HGNC id 15453
DNA
TYPE functioning gene
STRUCTURE 42.00 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
WDR26 1q42.12-q42.13 WD repeat domain 26 FLJ38993 1q42.13 hypothetical protein FLJ38993 MGC27277 1q42.13 hypothetical protein MGC27277 LOC388747 1 similar to RIKEN cDNA A230079K17 LOC127602 1q42.13 similar to KIAA1697 protein LBR 1q42.1 lamin B receptor ENAH 1q41 enabled homolog (Drosophila) SRP9 1q42.13 signal recognition particle 9kDa LEFTY3 1q42.1 LEFTY family pseudogene EPHX1 1q42.1 epoxide hydrolase 1, microsomal (xenobiotic) KIAA0792 1q42.13 epoxide hydrolase 1, microsomal (xenobiotic) LEFTB 1q42.1 left-right determination, factor B P5CR2 1q42.13 pyrroline 5-carboxylate reductase isoform EBAF 1q42.1 endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily) FLJ35382 1q42.13 hypothetical protein FLJ35382 H3F3A 1q41 H3 histone, family 3A ACBD3 1q42.13 acyl-Coenzyme A binding domain containing 3 MIXL1 1q41 Mix1 homeobox-like 1 (Xenopus laevis) TGS 1q42.13 TUDOR gene similar ADPRT 1q42 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) LOC391168 1 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 LOC391169 1 similar to hypothetical protein D11Ertd497e LOC388748 1 LOC388748 LOC388749 1 LOC388749 ITPKB 1q41-q42 inositol 1,4,5-trisphosphate 3-kinase B LOC391170 1 similar to hypothetical protein PSEN2 1q42.1 presenilin 2 (Alzheimer disease 4) CABC1 1q42.11 chaperone, ABC1 activity of bc1 complex like (S. pombe) CDC42BPA 1q42.11 CDC42 binding protein kinase alpha (DMPK-like) LOC343363 1q42.13 similar to basic transcription factor 3 LOC391171 1 similar to beta-tubulin 4Q LOC255208 1q42.13 HSA1q42.3 beta-tubulin 4Q pseudogene MGC42493 1q42.13 hypothetical protein MGC42493 MRP63P2 1q42.13 mitochondrial ribosomal protein 63 pseudogene 2 MGC15634 1q42.13 hypothetical protein MGC15634 FLJ12517 1q42.13 hypothetical protein FLJ12517 IMAGE3451454 1q42.13 SVAP1 protein MPN2 1q42.13 marapsin 2
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrine   highly
 thyroid   highly
Reproductivefemale systemovary  highly
 male systemtestis  highly
 male systemseminal vesicles  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousglia
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text in all tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PTB domain essential for NUMB activity
  • a proline-rich N terminal domain and an acyl-CoA-binding motif
  • a C terminal Golgi localization signal (NLS)
  • the GRID domain
  • a GOLGB1 binding domain
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY Golgin subfamily
    CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • colocalized with GOLGB1 to the juxtanuclear region
  • associates with the Golgi Apparatus (localizing to the cytoplasmic face of the Golgi membranes)
  • becomes cytosolic only during mitosis
  • basic FUNCTION
  • involved in the maintenance of Golgi structure and function through its interaction with giantin (GOLGB1)
  • affecting protein transport between the endoplasmic reticulum and Golgi
  • functioning as an A-kinase anchoring protein (AKAP) critical in the cAMP-dependent steroid formation
  • may participate in PRKAR1A-mediated tumorigenesis and hypercortisolism
  • having roles in the Golgi, is involved in posttranslational modification and trafficking of proteins but not required for the process of Golgi fragmentation, which is essential for cell-cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GOLGB1/giantin
  • interacting with NUMB through an essential NUMB domain (it is an essential NUMB partner in cell-fate specification)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS