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FLASH GENE
Symbol CYP4F12 contributors: mct/npt - updated : 30-06-2010
HGNC name cytochrome P450, family 4, subfamily F, polypeptide 12
HGNC id 18857
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 24.10 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • genetic polymorphism within the promoter region, associated with a decreased level of enzyme expression (Cauffiez 2004)
    • MAPPING cloned Y linked N status provisional
    regionally located located in the CYP4F cluster including CYP4F3 and CYP4F8
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1725 - 524 - Hashizume (2001)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
     liver   highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated HemoP
    mono polymer monomer
    HOMOLOGY
    intraspecies homolog to CYP4F2,CYP4F3
    Homologene
    FAMILY
  • cytochrome P450 family
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
    • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • oxydizing arachidonic acid and eicosanoid
  • physiological roles of CYP4F3 and CYP4F12 in eosinophils are different (Kikuta 2007)
  • metabolically active toward inflammatory mediators and exogenous compounds such as antihistaminic drugs (Cauffiez 2004)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein , other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
    • protein
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with NR1I2 (increased binding to NR1I2 in the presence of rifampicin) (Hariparsad 2009)
    • cell & other
    REGULATION
    Other regulated by NR1I2 (NR1I2 is involved in the regulation of CYP4F12 and along with SRC1 binds to a broad range of promoters but many of these are not inducible by rifampicin) (Hariparsad 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS