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FLASH GENE
Symbol RAET1E contributors: mct - updated : 16-03-2011
HGNC name retinoic acid early transcript 1E
HGNC id 16793
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text
  • major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster
  • STRUCTURE 2.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - RAET1F - RAET1G - ULBP2 - ULBP1 - RAET1J - RAET1K - RAET1L - RAET1M - ULBP3 - qter
    Authors Radosavljevic (01)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 885 30 263 - 2008 18544572
    - splicing - - - - 2008 18544572
  • type 1 membrane-spanning molecule having the ability to bind with KLRK1
  • ligand for KLRK1
  • - splicing - - - - 2008 18544572
  • type 1 membrane-spanning molecule having the ability to bind with KLRK1
  • ligand for KLRK1
  • - splicing - - - - 2008 18544572
  • type 1 membrane-spanning molecule having the ability to bind with KLRK1
  • ligand for KLRK1
  • - splicing - - - - 2008 18544572
  • ligand for KLRK1
  • - - 899 35 209 . in different tumor cells and tissues 2007 17470428
  • lacking the transmembrane region by selective splicing in tumor cells
  • may impair KLRK1-mediated NK cell cytotoxicity to tumors
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   predominantly
    Visualeyeanterior segmentcornea  
    cell lineage
    cell lines tumors cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • alpha 1 and alpha 2 domain
  • GPI domain
  • short hydrophilic cytoplasmic tail
  • one immunoglobulin-like domain
  • conjugated GlycoP
    mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
  • MHC class I superfamily
  • RAET1 family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • single-pass type I membrane protein, membrane-anchored
  • basic FUNCTION
  • stimulating lipid degradation in adipocytes and causing the extensive fat losses associated with some advanced cancers
  • being a ligand for the KLRK1
  • delivering activating signals to NK cells and promoting tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes
  • functions as a ligand for both TCRgammadelta and KLRK1 and may play a key role in immune surveillance of tumor development and clearance of viral infection
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • antigen processing and presentation
  • PATHWAY
    metabolism
    signaling
    a component
  • MHC class I protein complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to KLRK1/NKG2D
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary ovarian cancers with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS