single-pass type I membrane protein, membrane-anchored
basic FUNCTION
stimulating lipid degradation in adipocytes and causing the extensive fat losses associated with some advanced cancers
being a ligand for the KLRK1
delivering activating signals to NK cells and promoting tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes
functions as a ligand for both TCRgammadelta and KLRK1 and may play a key role in immune surveillance of tumor development and clearance of viral infection