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FLASH GENE
Symbol PPP1R14A contributors: mct - updated : 06-04-2011
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 14A
HGNC id 14871
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 5.30 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 723 16.7 147 smooth muscles 2001 11467857
  • CPI 17 alpha
  • 3 splicing 640 13.5 120 smooth muscles 2001 11467857
  • deletion of the 2nd coding exon of CPI 17 alpha
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmooth  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    Text expressed in embryonic heart
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    N terminal 67 residues highly conserved
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ppp1r14a
    Homologene
    FAMILY PP1 inhibitor family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • phosphorylation-dependent inhibitor of myosin phosphatase
  • causes a loss of merlin function characterized by merlin (NF2) phosphorylation, Ras activation and transformation
  • with DAPK3, participate in the regulation of PRKCA and PRKCE on vascular calcium sensitivity after hemorrhagic shock
  • playing a role in the regulation of endothelial cytoskeleton
  • phosphorylation-dependent inhibitor of smooth muscle myosin light chain
  • unique phosphoprotein that specifically inhibits myosin light chain phosphatase in smooth muscle and plays an essential role in agonist-induced contraction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • GNB2L1 is a novel interaction partner of PPP1R14A
  • cell & other
    REGULATION
    Other phosphorylated by PKN
    cooperative increases in Ca2+ and G protein activation are required for a significant activation of total kinases that phosphorylate PPP1R14A, which together overcome PPP1R14A phosphatase activity and effectively increase the Ca2+ sensitivity of PPP1R14A phosphorylation and smooth muscle contraction
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS