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FLASH GENE

Symbol

PGRMC2

contributors: npt - updated : 24-05-2005

HGNC name	progesterone receptor membrane component 2
HGNC id	16089

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.66 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed PGRMC2 3 - 1873 23.8 223 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, preferentially

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative transmembrane domain
	a highly conserved stretch of 58AA

HOMOLOGY

interspecies	homolog to murine Pgrmc2
	homolog to rattus 25Dx
	homolog to Drosophilia Cg9066

intraspecies

homolog to PGRMC1

Homologene

FAMILY	cytochrome b5 family
	MAPR subfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

receptor for progesterone

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	other,
	steroid (like progesterone)

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS