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FLASH GENE
Symbol FZD8 contributors: npt/mct - updated : 04-09-2013
HGNC name frizzled homolog 8 (Drosophila)
HGNC id 4046
DNA
TYPE functioning gene
STRUCTURE 3.19 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure ELK1- and PAX4-binding sites in the promoter
MAPPING cloned Y linked N status confirmed
Physical map
NRP1 10p12 neuropilin 1 PARD3 10p11.23 par-3 partitioning defective 3 homolog (C. elegans) CUL2 10p11.2-p11.1 cullin 2 CREM 10p12.1-p11.1 cAMP responsive element modulator C10orf9 10p11.22 chromosome 10 open reading frame 9 CX40.1 10p11.22 connexin40.1 FZD8 10p11.22 frizzled homolog 8 (Drosophila) LOC389947 10 similar to ribosomal protein L7 LOC387651 10 similar to Pre-B cell enhancing factor precursor LOC389948 10 similar to MAP kinase-interacting serine/threonine kinase 1; MAP kinase interacting kinase 1 NY-BR-1 10p11.21 breast cancer antigen NY-BR-1 LOC387652 10 similar to hypothetical protein MGC33214 LOC219752 10p11.21 similar to TACC1 protein LOC387653 10 similar to tousled-like kinase 2; serine/threonine kinase; tousled-like kinase ZNF248 10p11.2 zinc finger protein 248 LOC387654 10 LOC387654 BA775A3.1 10p11 KRAB box zinc finger protein pseudogene LOC389949 10 similar to zinc finger protein 11b (KOX 2) ZNF25 10p11.2 zinc finger protein 25 (KOX 19) ZNF33A 10p11.2 zinc finger protein 33a (KOX 31) LOC389950 10 LOC389950 LOC340947 10p11.21 similar to bA508N22.1 (HSPC025) ZNF37A 10p11.2 zinc finger protein 37a (KOX 21)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 3186 73.2 694 - 2001 11295046
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Endocrinepancreas   highly
 parathyroid   highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
Urinarykidney   highly
Visualeye   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines cervical uterus and lung cancers cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney, brain and lung, highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal peptide
  • two Asn-linked glycosylation sites within the N-terminal extracellular region
  • lys-thr-X-X-X-thr motif involved in the activation of the WNT/beta-catenin signaling pathway
  • a fz domain involved in binding with WNT ligands
  • a CRD
  • seven transmenbrane domains
  • three N-linked glycosylation sites
  • a C-terminal ser/thr-X-val motif which is a binding site for scaffold proteins with multiple PDZ domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Fzd8 (97.2 pc)
    homolog to murine Fzd8 (96.9 pc)
    intraspecies homolog to FZD5
    Homologene
    FAMILY
  • FZ/SMO family of G-protein coupled receptor
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • multi-pass membrane protein
  • basic FUNCTION
  • acting as a receptor for WNT proteins
  • coupled to the beta-catenin canonical signaling pathway, leading to the activation of dishvelled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta-catenin and activation of WNT target genes
  • playing a role in several types of human cancer through activation of the beta-catenin-TCF pathway
  • may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
  • may be functionally important for aberrant activation of the canonical Wnt signaling pathway in human lung cancer cells
  • may play an important role in aberrant activation of the canonical Wnt pathway which is critical for the proliferation and survival of lung cancer cells
  • FZD5 and FZD8 are involved in dose-dependent regulation of signaling in optic fissure/disc formation and progenitor expansion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
  • Wnt signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT receptor
  • scaffold proteins with multiple PDZ domains
  • interacting with GOPC
  • interacting with RSPO1 and RSPO3
  • binding to IGFBP4
  • IGFBP4 physically interacted with FZD8, and a Wnt co-receptor, LRP6, and inhibited the binding of WNT3A to FZD8 and LRP6
  • interacting with INVS (INVS is essential for the morphogenesis of the proximal and intermediate pronephric system and relays Frizzled-8–dependent signals to recruit Dishevelled to the plasma membrane)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical uterus and lung cancers
    tumoral     --over  
    in acute lymphoblastic leukaemia (ALL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    putative therapeutic target for human lung cancer
    ANIMAL & CELL MODELS