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FLASH GENE
Symbol HABP2 contributors: mct - updated : 17-03-2012
HGNC name hyaluronan binding protein 2
HGNC id 4798
DNA
TYPE functioning gene
STRUCTURE 38.77 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 3019 62.7 560 - 1996 8827452
13 - 2978 - 534 - 1996 8827452
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three epidermal growth factor (EGF)
  • a kringle domain
  • a serine protease domain
  • mono polymer heteromer , dimer
    isoforms Precursor circulates as a single-chain proenzyme (pro-PHBP), which is converted to an active, two-chain form through autoproteolysis
    HOMOLOGY
    interspecies homolog to murine Habp2
    Homologene
    FAMILY
  • peptidase S1 family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • glycosaminoglycan binding activity
  • can activate coagulation factor VII and prourokinase and release the vasoactive peptide bradykinin by cleaving kininogen
  • undergoes autoactivation in the presence of polyanionic macromolecules such as heparin and RNA
  • negatively regulates vascular integrity via activation of protease-activated receptor/RHOA/RHO kinase signaling
  • serine protease implicated in proteolysis under inflammatory conditions
  • circulating serine protease with high homology to fibrinolytic enzymes
  • important role in the regulation of the haemostasis system as well as fibroproliferative inflammatory processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer composed by a 50kDa protein and a 17kDa protein joined by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaves single chain urokinase-type plasminogen activator
  • Histone binds to pro-PHBP (histone-mediated pro-PHBP activation results in bradykinin formation, which is implicated in septic shock)
  • cell & other
    REGULATION
    activated by histone that promotes pro-PHBP autoactivation
    Other polyamine leakage from legions through cell death or tissue injury may account for physiologically relevant pro-HABP2 activation
    regulation of its activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to carotid stenosis and deep venous thrombosis (DVT)
    Variant & Polymorphism other
  • association of the 1601GA genotype with incidence and progression of carotid stenosis and deep venous thrombosis (DVT)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    potentially useful therapeutic target for syndromes of increased vascular permeability
    immunologyinfectious 
    selective inhibitors of pro-PHBP activation would be useful tools to treat septic shock
    ANIMAL & CELL MODELS