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FLASH GENE
Symbol STK33 contributors: mct/npt - updated : 04-09-2009
HGNC name serine/threonine kinase 33
HGNC id 14568
DNA
TYPE functioning gene
STRUCTURE 202.08 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2707 - 514 - Mujica (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis  highly
 male systemprostate   
Respiratorylung    
Visualeyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatogonia
Respiratoryalveolar macrophage
Respiratoryepithelial cell
Visualhorizontal association cell
cell lineage
cell lines
fluid/secretion
at STAGE
Text embryonic organs such as heart, brain and spinal cord (Mujica 2005)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • protein kinase superfamily
  • CAMK Ser/Thr protein kinase family
  • CaMK subfamily
  • CATEGORY enzyme , receptor membrane serine/threonine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • may be involved in protein amino acid phosphorylation
  • involved in the dynamics of the intermediate filament cytoskeleton by phosphorylating vimentin (Brauksiepe 2008)
  • acting as a component of a signaling pathway that is aberrantly required due to adaptation to a functionally relevant KRAS mutation (Scholl 2009)
  • selectively required for the survival and proliferation of mutant KRAS-dependent cancer cells across a wide range of tissue contexts (Scholl 2009)
  • promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through RPS6KB1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells (Scholl 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS