basic FUNCTION
| may be involved in protein amino acid phosphorylation |
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involved in the dynamics of the intermediate filament cytoskeleton by phosphorylating vimentin (Brauksiepe 2008) |
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acting as a component of a signaling pathway that is aberrantly required due to adaptation to a functionally relevant KRAS mutation (Scholl 2009) |
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selectively required for the survival and proliferation of mutant KRAS-dependent cancer cells across a wide range of tissue contexts (Scholl 2009) |
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promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through RPS6KB1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells (Scholl 2009) |