SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,inner
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| intracellular,cytoplasm,organelle,mitochondria,matrix
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| intracellular,cytoplasm,organelle,membrane
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text
| matrix protein and becomes cleaved at amino acid 28 after import into mitochondria |
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mainly localized in the mitochondria |
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SIRT4 is localized to mitochondria within the brain |
basic FUNCTION
| by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers |
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playing a role in the regulation of insulin secretion |
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lacks deacetylase activities but efficiently works as an ADP-ribosyltransferase |
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play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging |
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required to maintain cell survival after genotoxic stress in a NAD+-dependent manner |
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with SIRT3, modulate mitochondrial function in response to its [NADH]/[NAD+] ratio by regulating the activity of key metabolic enzymes |
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implicated in the regulation of insulin secretion by modulation of glutamate dehydrogenase |
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playing a role in regulating hepatic fat metabolism |
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is potentially a negative regulator of fat oxidation and overall mitochondrial oxidative metabolism |
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negative regulator of oxidative metabolism, which is in stark contrast to the functions of SIRT1 and SIRT3, which enhance the oxidative capacity of tissues |
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connected to keratinocyte differentiation, chronological aging, ultraviolet radiation (UVR) response, alopecia, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) |
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SIRT4 and GLUD1 overexpression play antagonistic roles in regulating gliogenesis |
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SIRT4 is an important regulator of lipid homeostasis |
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SIRT4 is a guardian of cellular metabolism |
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is a crucial regulator of the stress resistance of cancer cells |
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essential roles in stress resistance and may be an important therapeutic target for cancer treatment |
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SIRT4 is a crucial player maintaining insulin secretion and glucose homeostasis during aging |
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stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD+-dependent manner and is implicated in cellular senescence and aging |
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modulates energy homeostasis in multiple cell types and tissues |
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critical role for SIRT4 in the control of energy metabolism and meiotic apparatus during oocyte maturation and SIRT4 is an essential factor determining oocyte quality |
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in mitochondrial sirtuins, SIRT4 was the last of less well-understood mitochondrial sirtuins especially for its robust enzymatic activity |
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having robust deacylase activity in addition to the already accepted substrate-dependent lipoamidase and deacetylase properties |
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is proposed as either a mitochondrial tumor suppressor or a tumor-promoting protein in a context-dependent manner |