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FLASH GENE
Symbol ELMO3 contributors: mct/npt - updated : 25-08-2014
HGNC name engulfment and cell motility 3
HGNC id 17289
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 4.90 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • SP1-binding sites are likely to play an important role in regulating the ELMO3 promoter activity
  • MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 2548 - 773 - 2001 11595183
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinethyroid   highly
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • an ELMO domain
  • a PH domain
  • HOMOLOGY
    interspecies ortholog to C.elegans
    ortholog to Drosophila Ced12
    intraspecies paralog to ELMO1,ELMO2
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • upstream regulator of AKT1 required for engulfment of dying cells and for cell migration
  • involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility
  • unexpected role for ELMO1, ELMO2, ELMO3 in recruiting MACF1 at the membrane to promote efficient microtubule capture in cells spreading on fibronectin
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell communication
    PHYSIOLOGICAL PROCESS
    text cytoskeletal rearrangements during phagocytosis and cell motility in the late steps of the apoptotic process (complementation group 2 in C elegans)
    PATHWAY
    metabolism
    signaling
    signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
  • is an essential upstream regulator of the GTP-binding protein AKT1 during cell migration
  • CDX2 and SP1 can activate the ELMO3 promoter
  • MACF1 interacts with ELMO2 and ELMO3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS