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FLASH GENE
Symbol EIF3G contributors: mct - updated : 11-02-2012
HGNC name eukaryotic translation initiation factor 3, subunit G
HGNC id 3274
DNA
TYPE functioning gene
STRUCTURE 4.91 kb     11 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1127 - 320 - 1999 9973622
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   predominantly
Nervousnervecranial nerve  moderately
Reproductivefemale systemuteruscervix highly
 female systemovary  moderately
Respiratorylung   moderately
Skin/Tegumentskin   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal highly
cell lineage
cell lines Hela cells
fluid/secretion
at STAGE
physiological period embryo, fetal, pregnancy
Text embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RNA binding motif near its C terminus
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Tip35p
    homolog to rattus Eif3s4 (98.44 pc)
    homolog to murine Eif3g (98.44 pc)
    Homologene
    FAMILY eukaryotic translation initiation factor family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • stabilizing initiator Met tRNA (TRIMs) binding to 40S subunits
  • promoting the association of MET tRNA and mRNA
  • translation initiation factor EIF3 acts as the key orchestrator of the canonical initiation pathway in eukaryotes
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the EIF3 multiprotein complex, 600kDa
  • INTERACTION
    DNA
    RNA
  • binding to 40S ribosomal subunits
  • binding to the 18S RNA (required for mRNA binding)
  • binding beta-globin mRNA
  • small molecule
    protein
  • interacting EIF3A & EIF3S12
  • PELO interacts with HAX1, EIF3G and SRPX proteins and that this interaction occurs at the cytoskeleton
  • CTIF, which has been shown to be preferentially involved in NCBP1-dependent translation but not EIF4E-dependent translation, specifically interacts with EIF3G, a component of the EIF3 complex involved in ribosome recruitment
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS