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FLASH GENE
Symbol UGGT2 contributors: mct - updated : 19-11-2014
HGNC name UDP-glucose ceramide glucosyltransferase-like 2
HGNC id 15664
DNA
TYPE functioning gene
STRUCTURE 251.90 kb     39 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
39 - 4947 174.7 1516 - 2003 12913004
  • a 27 aa signal peptide of 2.8 kda
  • a 1489 aa mature peptide of172 kda
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
     vessel   moderately
    Digestiveliver    
    Endocrinepancreas    
     parathyroid   predominantly
    Hearing/Equilibriumear   highly
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Connectivebone  highly
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 27 aa signal pepide of 2.8 kda
  • a predicted ER-targeting signal sequence
  • a putative ER retrieval signal
  • four putative N-glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ugcgl2 (78.6 pc)
    intraspecies homolog to UGGT1
    Homologene
    FAMILY
  • glycosyltransferase 8 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text ER-Golgi intermediate compartment
    basic FUNCTION
  • recognizing glycoproteins with minor folding defects
  • reglucosylating single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum
  • having a glucosyltransferase activity, whose specificity was shown to be quite similar to UGGT1, in terms of both glycan specificity and preferential recognition of proteins having non-native conformations
    • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS
    text
  • protein glycosylation
    • PATHWAY
    metabolism
    signaling
    a component UGGT1 and UGGT2 are central component of the endoplasmic reticulum (ER) glycoprotein-folding quality control system, which prevents the exit of partially folded species
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Ca2+
  • Mn2+
    • protein
  • hormonal regulation of UGGT1 and UGGT2 expression and activity, which might influence the glycoprotein quality control mechanism
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS