SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,nucleus
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| localizes to mitochondria, and appears to be excluded, or largely absent from nuclei |
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specific isoforms are associated with the outer mitochondrial membrane, while the full-length OXR1 protein is predominately cytoplasmic( |
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basic FUNCTION
| may be involved in protection from oxidative damage |
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like its homologue, OXR1, NCOA7 is capable of reducing the DNA damaging effects of reactive oxygen species when expressed in bacteria, indicating the protein has an activity that can contribute to oxidation resistance |
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vital protein that controls the sensitivity of neuronal cells to oxidative stress |
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is potentially a novel neuroprotective factor in neurodegenerative disease |
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OXR1 and its close homolog NCOA7 are produced in many different forms either as a result of alternative splicing, or alternative transcription start sites |
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OXR1 as the first neuron-specific antioxidant modulator of pathogenesis and disease progression in SOD1-mediated amyotrophic lateral sclerosis |
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is a novel senolytic target that can be further exploited for the development of new senolytic agents |
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new molecular function for OXR1, establishing this protein as important player in neuronal survival, regulating both oxidative stress and glucose metabolism in the brain |
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OXR1 plays a critical role in lysosomal biology |