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FLASH GENE
Symbol GNA12 contributors: npt/mct - updated : 19-09-2016
HGNC name guanine nucleotide binding protein (G protein) alpha 12
HGNC id 4380
DNA
TYPE functioning gene
STRUCTURE 142.55 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ36166 7q22.1 hypothetical protein FLJ36166 LOC392700 7 similar to myelin protein zero-like 1; protein zero related LOC391995 7 similar to galectin-related inter-fiber protein ZNF138 7q11.21-q11.23 zinc finger protein 138 (clone pHZ-32) LOC392969 7 similar to Putative S100 calcium-binding protein A11 pseudogene LFNG 7p22 lunatic fringe homolog (Drosophila) CARD11 7p22 caspase recruitment domain family, member 11 LOC392769 7 similar to hypothetical protein FLJ32949 C7orf27 7p22.3 chromosome 7 open reading frame 27 LOC392944 7 similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glucosaminyl (N-acetyl) transferase 1, core 2; beta-1,6-N-acetylglucosaminyltransferase PMPCB 7q21.3-q22.1 peptidase (mitochondrial processing) beta KIAA1023 7p22.3 KIAA1023 protein LOC392931 7 hypothetical gene supported by AL834121 LOC392770 7 similar to M-phase phosphoprotein 11 PSMC2 7q22.1-q22.3 proteasome (prosome, macropain) 26S subunit, ATPase, 2 MGC12518 7q11.21 similar to ZINC FINGER PROTEIN 257 (BONE MARROW ZINC FINGER 4) (BMZF-4) PTPN12 7q11.23 protein tyrosine phosphatase, non-receptor type 12 PRES 7q22.1 prestin (motor protein) TTYH3 7p22 tweety homolog 3 (Drosophila) LOC392701 7 LOC392701 KIAA1950 7p22.3 KIAA1950 protein ZNF117 7q11.2 zinc finger protein 117 (HPF9) H-plk 7q11.21 Krueppel-related zinc finger protein LOC285919 7p22.3 hypothetical LOC285919 RELN 7q22 reelin GNA12 7p22-p21 guanine nucleotide binding protein (G protein) alpha 12 LOC392621 7 LOC392621 LOC392740 7 hypothetical gene supported by AF290475; BC037783 FLJ42526 7q21.11 FLJ42526 protein FLJ25037 7q11.21 hypothetical protein FLJ25037 C7orf35 7q21.11 chromosome 7 open reading frame 35 PHTF2 7q11.23-q21 putative homeodomain transcription factor 2 CARD11 7p22 caspase recruitment domain family, member 11 SDK1 7p22.3 sidekick homolog 1 (chicken) LOC392702 7 LOC392702
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4398 44.3 381 - 2008 18367648
3 - 4347 - 364 - 2008 18367648
5 - 4374 - 322 - 2008 18367648
3 - 4246 - 305 - 2008 18367648
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivefemale systemplacenta  highly
Visualeyeretina  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting sequence
  • PKD1 interaction sites are likely to reside on exposed regions within the G protein helical domain
  • secondary structure three units (alpha, beta, gamma)
    conjugated LipoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans F18G5.3
    homolog to murine Gna12
    Homologene
    FAMILY
  • G-alpha family
  • CATEGORY protooncogene , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • modulator or transducer in various transmembrane signaling systems
  • heterotrimeric G protein alpha subunit specifically targeted to mitochondria and involved in the control of mitochondrial morphology and dynamics
  • important regulator of prostate cancer invasion
  • has a major role in regulating epithelial cell apoptosis through PP2A and JNK activation leading to loss of BCL2 protein expression
  • involved inbstress fiber formation and neurite retraction
  • regulated expression of HTR7 and GNA12-protein may represent a molecular mechanism by which serotonin
  • modulates IgG production, thus induces IgG antibody-mediated immune responses
  • may be a critical signaling molecule in TCR-induced IL2 production and also relay a signal to suppress Th2 and Th17 cell differentiation
  • specifically modulates formation of initial neuronal networks during early postnatal development
  • GNA12 and GNA14 play a key role in the genetic architecture underlying normal gray matter density (GMD) variation in frontal and parietal regions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • MAPK8 activation is required for GNA12-induced invasion of breast cancer cells and MAPK8 is downstream of ROCK1 on this pathway
  • GNA12 plays a prominent role in endothelial cells (ECs) VWF secretion required for hemostasis and thrombosis
  • interaction of polycystin-1 (PKD1) and GNA12 is important for development of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD)
  • CDH1/CTNNB1 signaling pathway is regulated by PKD1 and GNA12 via ADAM10
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • RGS22 had specific interactions with the heterotrimeric G protein GNA12 and GNA13 in the cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    constitutional     --over  
    higher in preeclampsia patients than in controls, by decreased methylation level
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality
    ANIMAL & CELL MODELS