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Symbol GNA12 contributors: npt/mct - updated : 19-09-2016
HGNC name guanine nucleotide binding protein (G protein) alpha 12
HGNC id 4380
TYPE functioning gene
STRUCTURE 142.55 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ36166 7q22.1 hypothetical protein FLJ36166 LOC392700 7 similar to myelin protein zero-like 1; protein zero related LOC391995 7 similar to galectin-related inter-fiber protein ZNF138 7q11.21-q11.23 zinc finger protein 138 (clone pHZ-32) LOC392969 7 similar to Putative S100 calcium-binding protein A11 pseudogene LFNG 7p22 lunatic fringe homolog (Drosophila) CARD11 7p22 caspase recruitment domain family, member 11 LOC392769 7 similar to hypothetical protein FLJ32949 C7orf27 7p22.3 chromosome 7 open reading frame 27 LOC392944 7 similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glucosaminyl (N-acetyl) transferase 1, core 2; beta-1,6-N-acetylglucosaminyltransferase PMPCB 7q21.3-q22.1 peptidase (mitochondrial processing) beta KIAA1023 7p22.3 KIAA1023 protein LOC392931 7 hypothetical gene supported by AL834121 LOC392770 7 similar to M-phase phosphoprotein 11 PSMC2 7q22.1-q22.3 proteasome (prosome, macropain) 26S subunit, ATPase, 2 MGC12518 7q11.21 similar to ZINC FINGER PROTEIN 257 (BONE MARROW ZINC FINGER 4) (BMZF-4) PTPN12 7q11.23 protein tyrosine phosphatase, non-receptor type 12 PRES 7q22.1 prestin (motor protein) TTYH3 7p22 tweety homolog 3 (Drosophila) LOC392701 7 LOC392701 KIAA1950 7p22.3 KIAA1950 protein ZNF117 7q11.2 zinc finger protein 117 (HPF9) H-plk 7q11.21 Krueppel-related zinc finger protein LOC285919 7p22.3 hypothetical LOC285919 RELN 7q22 reelin GNA12 7p22-p21 guanine nucleotide binding protein (G protein) alpha 12 LOC392621 7 LOC392621 LOC392740 7 hypothetical gene supported by AF290475; BC037783 FLJ42526 7q21.11 FLJ42526 protein FLJ25037 7q11.21 hypothetical protein FLJ25037 C7orf35 7q21.11 chromosome 7 open reading frame 35 PHTF2 7q11.23-q21 putative homeodomain transcription factor 2 CARD11 7p22 caspase recruitment domain family, member 11 SDK1 7p22.3 sidekick homolog 1 (chicken) LOC392702 7 LOC392702
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4398 44.3 381 - 2008 18367648
3 - 4347 - 364 - 2008 18367648
5 - 4374 - 322 - 2008 18367648
3 - 4246 - 305 - 2008 18367648
Type widely
   expressed in (based on citations)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivefemale systemplacenta  highly
Visualeyeretina  highly
cell lineage
cell lines
  • N-terminal mitochondrial targeting sequence
  • PKD1 interaction sites are likely to reside on exposed regions within the G protein helical domain
  • secondary structure three units (alpha, beta, gamma)
    conjugated LipoP
    mono polymer heteromer , trimer
    interspecies homolog to C.elegans F18G5.3
    homolog to murine Gna12
  • G-alpha family
  • CATEGORY protooncogene , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • modulator or transducer in various transmembrane signaling systems
  • heterotrimeric G protein alpha subunit specifically targeted to mitochondria and involved in the control of mitochondrial morphology and dynamics
  • important regulator of prostate cancer invasion
  • has a major role in regulating epithelial cell apoptosis through PP2A and JNK activation leading to loss of BCL2 protein expression
  • involved inbstress fiber formation and neurite retraction
  • regulated expression of HTR7 and GNA12-protein may represent a molecular mechanism by which serotonin
  • modulates IgG production, thus induces IgG antibody-mediated immune responses
  • may be a critical signaling molecule in TCR-induced IL2 production and also relay a signal to suppress Th2 and Th17 cell differentiation
  • specifically modulates formation of initial neuronal networks during early postnatal development
  • GNA12 and GNA14 play a key role in the genetic architecture underlying normal gray matter density (GMD) variation in frontal and parietal regions
    signaling signal transduction
    a component
    small molecule
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • MAPK8 activation is required for GNA12-induced invasion of breast cancer cells and MAPK8 is downstream of ROCK1 on this pathway
  • GNA12 plays a prominent role in endothelial cells (ECs) VWF secretion required for hemostasis and thrombosis
  • interaction of polycystin-1 (PKD1) and GNA12 is important for development of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD)
  • CDH1/CTNNB1 signaling pathway is regulated by PKD1 and GNA12 via ADAM10
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • RGS22 had specific interactions with the heterotrimeric G protein GNA12 and GNA13 in the cells
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    constitutional     --over  
    higher in preeclampsia patients than in controls, by decreased methylation level
    Variant & Polymorphism
    Candidate gene
    Therapy target may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality