Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GNA13 contributors: mct - updated : 06-04-2013
HGNC name guanine nucleotide binding protein (G protein), alpha 13
HGNC id 4381
DNA
TYPE functioning gene
STRUCTURE 47.51 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CSHL1 17q23.3-q24.2 chorionic somatomammotropin hormone-like 1 GH1 17q24 growth hormone 1 CD79B 17q23 CD79B antigen (immunoglobulin-associated beta) SCN4A 17q23 sodium channel, voltage-gated, type IV, alpha ICAM2 17q23-q25 intercellular adhesion molecule 2 ERN1 16p12 ER to nucleus signalling 1 FLJ30999 17q24.2 hypothetical protein FLJ30999 HT008 17q24.2 uncharacterized hypothalamus protein HT008 LOC253013 17q24.2 similar to ribosomal protein L31 PECAM1 17q23 platelet/endothelial cell adhesion molecule (CD31 antigen) LOC284021 17q24.2 hypothetical protein LOC284021 POLG2 17q polymerase (DNA directed), gamma 2, accessory subunit DDX5 17q21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 LOC90799 17q24.2 hypothetical protein BC009518 SMURF2 17q22-q23 hypothetical protein BC009518 LOC388411 17 similar to Importin alpha-2 subunit (Karyopherin alpha-2 subunit) (SRP1-alpha) (RAG cohort protein 1) LOC390807 17 hypothetical gene supported by AK097700 MGC40489 17q24 hypothetical protein MGC40489 LOC388412 17 LOC388412 KIAA0563 17q24.2 LOC388412 LOC390808 17 similar to solute carrier family 16, member 6; monocarboxylate transporter 6 LOC284020 17q24.2 similar to solute carrier family 16, member 6; monocarboxylate transporter 6 FLJ32065 17q24.2 hypothetical protein FLJ32065 GNA13 17q24 guanine nucleotide binding protein (G protein), alpha 13 RGS9 17q24 regulator of G-protein signalling 9 AXIN2 17q23-q24 axin 2 (conductin, axil) MGC33887 17q24.2 hypothetical protein MGC33887
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 6311 44 377 - -
- - 5300 - - Jurkat and HPB-ALL leukemic T cell lines -
minor
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunelymph node   highly
 thymus   highly
cell lineage
cell lines HPB-ALL leukemic T cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to C.elegans F18G5.3
Homologene
FAMILY
  • G alpha family
  • G(12) subfamily
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • participating in the regulation of cell movement in response to specific ligands and in developmental angiogenesis
  • involved as modulators or transducers in various transmembrane signaling systems
  • regulating cell growth and differentiation through the monomeric Rho GTPase
  • required for the embryonic angiogenesis (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • three units : alpha, beta and gamma
  • the alpha chain contains the guanine nucleotide binding site
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ARHGEF1
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • ITK interacts with GNA13 during TCR triggering, and this interaction results in tyrosine phosphorylation of GNA13
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • RGS22 had specific interactions with the heterotrimeric G protein GNA12 and GNA13 in the cells
  • cell & other
    REGULATION
    Other regulated by myocyte-specific enhancer factor-2 (MEF2) mediating GNA13-dependent angiogenesis (Liu 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of endogenous GNA13 and MEF2 proteins in endothelial cells reduced cell proliferation and capillary tube formation (Liu 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS