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FLASH GENE
Symbol HRH4 contributors: - updated : 19-07-2007
HGNC name histamine receptor H4
HGNC id 17383
DNA
TYPE functioning gene
STRUCTURE 19.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 liver   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   lowly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP , LipoP
HOMOLOGY
interspecies homolog to chimpanzee HRH4 (98.7 pc)
homolog to rattus Hrh4 (69.9 pc)
homolog to murine Hrh4 (68.9 pc)
intraspecies homolog to HRH3
Homologene
FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • could mediate the histamine signals in peripheral tissues
  • acting as an histamine receptor
  • acting as a rhodopsin-like receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other expression is either up-regulated or down-regulated upon activation of the lymphoid tissues and this regulation may depend on the presence of IL-10 or IL-13
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS