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FLASH GENE
Symbol DDX10 contributors: - updated : 21-04-2006
HGNC name DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
HGNC id 2735
DNA
TYPE functioning gene
STRUCTURE 275.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
GRIA4 11q22.3 glutamate receptor, ionotrophic, AMPA 4 KIAA1826 11q22 KIAA1826 protein KBTBD3 11q22.3 kelch repeat and BTB (POZ) domain containing 3 AASDHPPT 11q22 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase GUCY1A2 11q21-q22 guanylate cyclase 1, soluble, alpha 2 LOC341230 11q23.1 similar to argininosuccinate synthetase FLJ32343 11q23.1 hypothetical protein FLJ32343 LOC91801 11q23.1 hypothetical protein BC015183 DKFZp547C176 11q23.1 hypothetical protein DKFZp547C176 SLN 11q22-q23 sarcolipin LOC203930 11q23.1 sorting nexin 7 pseudogene SLC35F2 11q23.1 solute carrier family 35, member F2 RAB39 11q22-q23 RAB39, member RAS oncogene family CUL5 11q22-q23 cullin 5 ACAT1 11q22.3 acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) NPAT 11q22-q23 nuclear protein, ataxia-telangiectasia locus ATM 11q22.3 ataxia telangiectasia mutated (includes complementation groups A, C and D) MGC33948 11q23.1 hypothetical protein MGC33948 MGC33424 11q23.1 hypothetical protein MGC33424 SLAC2-B 11q23.1 hypothetical protein MGC33424 DDX10 11q22-q23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 HCP29 11q22.3 cytochrome c, somatic pseudogene LOC260340 11q23.1 processed pseudogene mtTFA 2 LOC390249 11 similar to 40S ribosomal protein SA (P40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance-associated protein MGr1-Ag) LOC390250 11 similar to RPB5_Human KIAA1726 11q23.1 KIAA1726 protein RDX 11q22.3-q23.1 radixin FDX1 11q22.3-q23.1 ferredoxin 1 ARHGAP20 11q23.2 Rho GTPase activating protein 20 LOC120364 11q23.2 similar to Hnrpa1 protein MGC50104 11q23.2 Similar to RIKEN cDNA 1810046K07 gene LOC120376 11q23.2 hypothetical protein LOC120376 POU2AF1 11q23.1 POU domain, class 2, associating factor 1 BTG4 11q23.2-q23.3 B-cell translocation gene 4 LOC387807 11 hypothetical gene supported by AK128145; BC039505 LOC143903 11q23.2 layilin SIK2 11q23.2 salt-inducible serine/threonine kinase 2 PPP2R1B 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform DIBD1 11q23 disrupted in bipolar affective disorder 1 C11orf1 11p15.5 chromosome 11 open reading frame 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Reproductivemale systemtestis  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
DEAD/H box (Asp-Glu-Ala-Asp/His), helicase C terminal domain
HOMOLOGY
Homologene
FAMILY DEAD/H box protein 10 family
CATEGORY enzyme , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
basic FUNCTION RNA helicase with RNA dependent ATPase activity, may be involved in ribosome assembly
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral fusion      
with NUP98 in de novo or therapy related myeloid malignancies with inv 11(p15-q22)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS