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FLASH GENE
Symbol SF3B3 contributors: mct - updated : 20-02-2018
HGNC name splicing factor 3b, subunit 3, 130kDa
HGNC id 10770
DNA
TYPE functioning gene
STRUCTURE 53.88 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 - 9736 - 1217 - 2002 12234937
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text umbilical vein
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to yeast S.cerevisiae sap130
Homologene
FAMILY
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
text
  • localizes in both the nucleus and the cytoplasm
  • basic FUNCTION
  • required for the assembly of the spliceosomal complex
  • is a cullin binding protein that is likely involved in the NEDD8 pathway
  • role of SF3B3 in endocrine resistance and prognosis in ER-positive breast cancer
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the "a" complex in the spliceosome assembly pathway
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • U2SnRNP,U11/U12SnRNP associated splice protein
  • associating with other SF3B proteins, interacting with SAP155, (SF3B1)
  • may likely link Cullin-RING ubiquitin E3 ligases (CRLs) mediated ubiquitination to gene expression
  • SF3B3 binds to several Cullin proteins
  • its overexpression reduces the binding of adaptor protein SKP1 and substrate receptor SKP2 to CUL1, whereas it has no effect on CAND1 binding to CUL1
  • MCM7 binds SF3B3, and the binding motif is located in the N terminus (amino acids 221-248) of MCM7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS