basic FUNCTION
| potential cellular regulator modulating multiple signaling pathways |
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coactivator increasing the target specificity of AP-1 transcription factor |
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cleaving through JAMM domain NEDD8 from the CUL1 subunit of SCF ubiquitin ligase |
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phosphorylating IKBA, JUN, NFKB1 |
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involved in numerous cell processes, including regulation of transcription and protein turnover |
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regulating the transcriptional activity of HAND2 in a unique manner that may account, in part, for the apparent ability of this bHLH factor to regulate gene expression through numerous mechanisms |
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important effector that mediates a novel signal transduction pathway for F2RL1-dependent gene expression |
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having a function critical for the proliferation and maintenance of hematopoietic progenitors |
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COPS5 and BCL2L14 co-expression synergistically induces apoptosis |
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playing a critical role for cell proliferation/survival and the eventual pathway to control tumorigenesis |
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negative regulator of TP53 and a plausible oncogene |
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implicated in regulating TP53 activity and is overexpressed in various tumors |
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regulates the degradation rate of EDNRA and EDNRB by modulating ubiquitination of these receptors, leading to changes in EDNRA and EDNRB levels |
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promotes degradation of EDNRA by enhancing its ubiquitination |
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multifunctional protein that participates in the control of cell proliferation and the stability of multiple protein |
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essential for efficient DNA repair and mechanistically linked to the maintenance of genome integrity and to cell survival |
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important regulator in cancer development |
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affects RAD51 protein expression through TP53 transcriptional regulation |
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controls different events of the cell cycle, preventing senescence and endocycle as well as the proper progression of the somatic cell cycle |
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regulates ubiquitin-dependent protein degradation by deneddylation of cullin-based ubiquitin ligases and, therefore, plays a central role in regulating proliferation and apoptosis |
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represses chondrocyte hypertrophy, likely in part by downregulating BMP signaling and RUNX2 activity |
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endothelial COPS5 attenuates NFKB-dependent pro-inflammatory gene expression suggesting that it might serve as a negative regulator of atherogenesis |
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role as a multifunctional cell cycle regulator |
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COPS5 is a RANBP9-interacting protein that robustly increases APP generation |
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COPS5 may play a pathological role in AD |
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positively regulates the basal protein stability of IFN receptor and the IFN response by antagonizing the neddylation pathway (pMID: 24043623) |
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has a positive role in the IFNA-induced cell responses (pMID: 24043623) |
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may constitute a key molecule in the pathogenesis of dysmyelinating neuropathies (pMID: 24344238) |