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FLASH GENE
Symbol SPTBN5 contributors: - updated : 03-09-2007
HGNC name spectrin, beta, non-erythrocytic 5
HGNC id 15680
DNA
TYPE functioning gene
STRUCTURE 45.00 kb     68 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text the first exon may be alternatively spliced
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
 mouth    
 salivary gland    
 stomach   highly
endocrinebraindiencephalonpituitary highly
Endocrinepancreas   highly
Nervousbrain   highly
 brainhindbraincerebellum highly
 spinal cord   highly
Urinarybladder   highly
 kidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
thirty spectrin repeats,an actin-binding domain,a membrane association domain one,a self association and a pleckstrin homology domains near the C terminus
mono polymer heteromer , dimer , polymer
HOMOLOGY
interspecies ortholog to Drosophila beta heavy spectrin
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytoskeleton
text
  • actin cytoskeleton associated
  • vesicles of the secretory/endocytic pathway
  • basic FUNCTION
  • cell structure
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterodimers and oligomers with alpha spectrin
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • actin
  • cell & other
  • interact directly with cellular mempbranes
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS