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FLASH GENE
Symbol TMEM123 contributors: KTN/npt - updated : 15/12/2008
HGNC name transmembrane protein 123
HGNC id 30138
DNA
TYPE functioning gene
STRUCTURE 56.72 kb     5 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3605 - 208 - -
  • a 26 aa signal peptide of 2.5 kda
  • a 182 aa mature peptide of 19 kda
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     liver   moderately
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunelymph node   highly
     thymus   moderately
    Nervousnerve   highly
    Respiratoryrespiratory tracttrachea  predominantly
    Skin/Tegumentskin   moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney, liver, spleen, thymus, lung
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracellular domain containing many O-linked
  • seven N-linked-glycosilation sites
  • hydrophobic transmembrane domain (ZOAA)
  • a cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog TMEM123 (61.7 pc)
    homolog to chimpanzee TMEM123 (98.6 pc)
    homolog to cow TMEM123 (63.5 pc)
    homolog to rattus Tmem123 (57.1 pc)
    homolog to murine Tmem123 (56.6 pc)
    intraspecies homolog to CD164, endolyn
    Homologene
    FAMILY
  • membrane mucin family
  • CD164 family
  • CATEGORY regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS