basic FUNCTION
| inhibiting signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form |
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involved in the induction of endothelial apoptosis, antagonizing the angiogenic effect of VEGF by increasing the activation of p38 signaling |
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crucial component of the signaling pathway involved in cardiac remodeling and heart failure |
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its cardiac constitutive expression protects against cardiac hypertrophy and fibrosis by blocking MEK-ERK1/2 signaling |
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role in maintaining cardiac contractility and in reducing fibrosis in response to hypertrophic stimuli |
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RGS5 and DLX1 represent novel molecular targets for the regulation of ductus arteriosus (DA) maturation and closure |
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promotes arterial growth during arteriogenesis |
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RGS5 is a mechanosensitive regulatory protein that is required to promote the synthetic vascular smooth muscle cells (VSMCs) phenotype as a prerequisite for structural renovation of the arterial wall during hypertension |
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RGS5 expression and activity in neutrophils determine likely their migrational patterns in the complex microenvironments characteristic of inflamed tissues |
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tissue& |
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8209;speci& |
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64257;c signal& |
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8209;regulating molecule, playing a key role in the development of the vasculature |
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plays a key role in angiogenesis in ovarian carcinoma |
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endothelial RGS5 plays a novel neuroprotective role in focal cerebral ischemia |
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promotes neurodegenerative process through augmenting astrocytic tumor necrosis factor receptor (TNFRSF1A) signaling |