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FLASH GENE
Symbol RGS5 contributors: mct - updated : 17-01-2024
HGNC name regulator of G-protein signaling 5
HGNC id 10001
DNA
TYPE functioning gene
STRUCTURE 179.44 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 5756 - 73 - 2022 36111549
3 - 5497 - 73 highly expressed in the ciliary body and trabecular meshwork, in the eye, and in the kidney, brain, spleen, skeletal muscle and small intestine, but was not detectable in the liver, lung, heart 2022 36111549
  • also called RGS5s
  • 108 amino acid N-terminal deletion
  • may contain functional domains that compete with RGS5 in the regulation of the Galphaq coupled AT1 and FP receptors
  • may play a critical role in the regulation of intracellular signaling pathways
  • 5 - 5927 - 181 - 2022 36111549
  • present in both membrane and cytosolic fractions
  • N-terminal may be important for protein translocation to the cell membrane
  • inhibited the Ca2+ signaling initiated by activation of Galphaq coupled angiotensin II receptors (AT1) and prostaglandin FP receptors
  • 7 - 5825 - 188 - 2022 36111549
    7 - 5844 - 73 - 2022 36111549
    8 - 5913 - 188 - 2022 36111549
    6 - 5769 - 167 - 2022 36111549
    7 - 5866 - 73 - 2022 36111549
    8 - 5958 - 73 - 2022 36111549
    9 - 5935 - 188 - 2022 36111549
    9 - 6023 - 188 - 2022 36111549
    5 - 5682 - 185 - 2022 36111549
    EXPRESSION
    Rna function high levels of RGS5 mRNA in heart tissue
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinesmall intestine  highly
     liver   lowly
    Endocrineadrenal gland   highly
    Nervousnerve   highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularsmoothvessel highly Homo sapiens
    Muscularstriatumskeletal highly Homo sapiens
    Muscularstriatumcardiac highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Blood/Hematopoieticneutrophil Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal (1-33) playing a role in targeting this protein to membranes, and not essential for exerting activities
  • a RGS domain with three conserved motifs GH1, GH2, GH3,
  • a C terminal coiled-coil domain
  • one regulator of G protein signaling domain
  • HOMOLOGY
    interspecies homolog to yeast SST2
    Homologene
    FAMILY
    CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text strongly expressed in vessels during angiogenesis
    basic FUNCTION
  • inhibiting signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
  • involved in the induction of endothelial apoptosis, antagonizing the angiogenic effect of VEGF by increasing the activation of p38 signaling
  • crucial component of the signaling pathway involved in cardiac remodeling and heart failure
  • its cardiac constitutive expression protects against cardiac hypertrophy and fibrosis by blocking MEK-ERK1/2 signaling
  • role in maintaining cardiac contractility and in reducing fibrosis in response to hypertrophic stimuli
  • RGS5 and DLX1 represent novel molecular targets for the regulation of ductus arteriosus (DA) maturation and closure
  • promotes arterial growth during arteriogenesis
  • RGS5 is a mechanosensitive regulatory protein that is required to promote the synthetic vascular smooth muscle cells (VSMCs) phenotype as a prerequisite for structural renovation of the arterial wall during hypertension
  • RGS5 expression and activity in neutrophils determine likely their migrational patterns in the complex microenvironments characteristic of inflamed tissues
  • tissue&
  • 8209;speci&
    64257;c signal&
    8209;regulating molecule, playing a key role in the development of the vasculature
  • plays a key role in angiogenesis in ovarian carcinoma
  • endothelial RGS5 plays a novel neuroprotective role in focal cerebral ischemia
  • promotes neurodegenerative process through augmenting astrocytic tumor necrosis factor receptor (TNFRSF1A) signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text promoting chondrocyte differentiation
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to GNAI1 and GNAO1, but not to GNAS
  • binding of GPSM3 to RGS5 appears to be selective as no interactions were detected with other RGS proteins
  • RGS5 likely inhibits SHH function during neurite outgrowth and the presynaptic terminals of primary cortical neurons mature via modulation of cAMP
  • dysregulated (RGS5-mediated) AGTR1 signaling could likely contribute to excessive vasoconstriction in hypertension
  • cell & other
    REGULATION
    induced by HIF1-dependent hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in clear cell renal carcinoma with good outcome
    tumoral     --over  
    in epithelial ovarian cancer (EOC) compared with the normal ovaries
    constitutional     --low  
    RGS5 expression in myometrial vessels is markedly suppressed in gestational hypertension and/or preeclampsia
    Susceptibility to essential hypertension
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    its signaling pathway may serve as anti‑angiogenesis targets for the treatment of ovarian cancer
    cancer  
    could be an important target for apoptotic therapy
    cardiovascularcardiomyopathy 
    treatment of cardiac hypertrophy through targeting of the RGS5 signaling pathway
    cardiovascularatheroma 
    preservation of endothelial RGS5 may be an important therapeutic strategy for maintaining blood-brain barrier integrity and limiting the severity of ischemic stroke
    ANIMAL & CELL MODELS
  • Rgs5(-/-) mouse hearts showed significantly prolonged cardiac repolarization, including prolonged QT interval and action potential duration (APD).
  • Rgs5 deficiency leads to elevated blood pressure and deleterious cerebral vascular outcomes in aged mice