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FLASH GENE
Symbol PANK1 contributors: mct - updated : 26-10-2016
HGNC name pantothenate kinase 1
HGNC id 8598
DNA
TYPE functioning gene
STRUCTURE 62.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure six exons for the core protein
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal proline-rich domain
  • a glycine-rich domain
  • a polyglycine-serine region
  • a basic helix-loop-helix (bHLH) domain
  • a C-terminal alanine-rich region
  • HOMOLOGY
    interspecies ortholog to murine Pank1
    intraspecies paralog to PANKS
    Homologene
    FAMILY
  • basic helix-loop-helix (bHLH) family of transcription factors
  • Olig family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • first committed step of universal CoA biosynthesis
  • catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5) and derivatives
  • PANK1 and PANK2 can compensate for each other to supply tissue CoA, but PANK1 is more important to CoA levels in liver whereas PANK2 contributes more to CoA synthesis in the brain
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism vitamin
    signaling
    regulatory enzyme of CoA biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS