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FLASH GENE
Symbol SIRPG contributors: - updated : 01-04-2006
HGNC name signal-regulatory protein gamma
HGNC id 16247
DNA
TYPE functioning gene
STRUCTURE 28.00 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
 thymus    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transmembrane short intracellular domain
  • putative signal sequence
  • a long extracellular domain
  • three immunoglobulin (Ig) domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to SIRPB1
    Homologene
    FAMILY SIRP/SHPS-1 protein family
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein like PTPNS1, it binds CD47(SIRPG-CD47 interaction may therefore not be capable of bidirectional signaling as with the PTPNS1-CD47, but, instead, use unidirectional signaling via CD47 only)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS