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FLASH GENE
Symbol ABCC11 contributors: mlc - updated : 12-04-2006
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 11
HGNC id 14639
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem, opposite orientation
text tandemly located in a tail-to-head orientation with ABCC12
STRUCTURE 65.00 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 4590 - 1382 highly in breast cancer Dean,Bera
- splicing 4862 - 1382 - Dean
- splicing 4476 - 1344 testis Dean,Bera
lacking exon 9
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Nervousbrain   lowly
Reproductivefemale systembreastmammary gland  
 male systemprostate  lowly
 male systemtestis  moderately
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text lowly in placenta and fetal brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP-binding domains
  • two transmembrane regions
  • HOMOLOGY
    intraspecies homolog to MRP5
    Homologene
    FAMILY ATP binding cassette transporter subfamily C (CFTR/MRP)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text co-localized with neurofilaments indicating that it is an axonal protein
    basic FUNCTION
  • acting as a multispecific organic anion pump which can transport nucleotides
  • involved in multi-drug resistance
  • playing a role in dehydroepiandrosterone 3-sulfate release from neurons to sites of dehydroepiandrosterone 3-sulfate-mediated receptor modulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP-binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility to earwax type
    Variant & Polymorphism SNP determinant of earwax type
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS