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FLASH GENE

Symbol

PTPN4

contributors: mct/npt/pgu - updated : 22/10/2008

HGNC name	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
HGNC id	9656

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	217.83 kb     27 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002830 27 splicing 3963 NP_002821 105.8 926 - 2000 11054567 variant 2 - splicing 3200 isoform 2 - - testis (spermatocytes, spermatids) 2000 11054567

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       predominantly Lymphoid/Immune spleen       highly   thymus       highly   tonsils       moderately Nervous brain hindbrain cerebellum     Reproductive male system testis     moderately Respiratory respiratory tract larynx     moderately   respiratory tract trachea     moderately

cells

System Cell Pubmed Species Stage Rna symbol Nervous Purkinje cell

cell lineage
cell lines
fluid/secretion	moderately in lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a PTP domain, with FERM (Band 4.1, Ezrin, Radixin, and Moesin) domain
	a PDZ domain dual specificity phosphatase catalytic domain
	tyrosine-protein phosphatase domain

HOMOLOGY

interspecies	homolog to rattus Ptpn4 (95.6 pc)
	homolog to murine Ptpn4 (94.7 pc)

intraspecies

homolog to erythrocyte protein 4.1

Homologene

FAMILY	protein-tyrosine phosphatase family
	non-receptor class subfamily
	PTPH1-family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton
text	extrinsic to membrane
	located at the cytoplasmic face of the plasma membrane

basic FUNCTION	involved in the junctions between the membrane and the cytoskeleton
	capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, and is dispensable for T cell development and/or T cell effector functions
	with PTPN3 are dispensable for TCR signal transduction
	regulating tyrosine dephosphorylation (important for both motor learning and cerebellar synaptic plasticity)
	having a a regulatory role in T cell activation
	may be involved in regulation of the membrane cytoskeleton, signal transduction, or both

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS