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FLASH GENE
Symbol PTPN4 contributors: mct/npt/pgu - updated : 22/10/2008
HGNC name protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
HGNC id 9656
DNA
TYPE functioning gene
STRUCTURE 217.83 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 splicing 3963 105.8 926 - 2000 11054567
- splicing 3200 - - testis (spermatocytes, spermatids) 2000 11054567
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   predominantly
Lymphoid/Immunespleen   highly
 thymus   highly
 tonsils   moderately
Nervousbrainhindbraincerebellum  
Reproductivemale systemtestis  moderately
Respiratoryrespiratory tractlarynx  moderately
 respiratory tracttrachea  moderately
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion moderately in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PTP domain, with FERM (Band 4.1, Ezrin, Radixin, and Moesin) domain
  • a PDZ domain dual specificity phosphatase catalytic domain
  • tyrosine-protein phosphatase domain
  • HOMOLOGY
    interspecies homolog to rattus Ptpn4 (95.6 pc)
    homolog to murine Ptpn4 (94.7 pc)
    intraspecies homolog to erythrocyte protein 4.1
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class subfamily
  • PTPH1-family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text
  • extrinsic to membrane
  • located at the cytoplasmic face of the plasma membrane
  • basic FUNCTION
  • involved in the junctions between the membrane and the cytoskeleton
  • capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, and is dispensable for T cell development and/or T cell effector functions
  • with PTPN3 are dispensable for TCR signal transduction
  • regulating tyrosine dephosphorylation (important for both motor learning and cerebellar synaptic plasticity)
  • having a a regulatory role in T cell activation
  • may be involved in regulation of the membrane cytoskeleton, signal transduction, or both
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS