SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus,nucleoplasm,nuclear bodies,PML
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text
| localizes at the mitotic spindle during mitosis and plays a role in centrosome separation at the beginning of mitosis with a subsequent delay of the mitotic progression and impact on chromosomal stability |
basic FUNCTION
| may be a regulator of SOCS-1 function |
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acting as a E3 ubiquitin ligase |
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modulates translocation of phosphorylated STAT3 into the nucleus through interaction with HSP90AB1 and consequently regulates transcription of NANOG in embryonic stem cells |
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positive regulator of TNF and interleukin-1beta (IL1B)–triggered NFKB activation |
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required for TNF- and IL1B–triggered NFKB activation and induction of inflammatory proteins |
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positively regulates TNF induced NFKB pathway |
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also enhanced the clonogenic and migration ability of cells by modulating NFKB |
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E3 ligase ubiquitously expressed in various cells, that is closely involved in innate immunity |
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TRIM8 regulates lysosomal biogenesis and autophagy flux |
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TRIM8 regulated autophagy is essential for its cytoprotective role during genotoxic stress induced cell death |
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is a novel regulator of DNA damage response (DDR)-autophagy crosstalk, which may play role in survival of cancer cells in presence of genotoxic agents |
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is required for virus-induced IFN response in plasmacytoid dendritic cells |
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TRIM8 encodes an E3 ubiquitin ligase involved in various pathological processes, including hypertrophy, antiviral defense, encephalopathy, and cancer development |
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tripartite E3 ubiquitin ligase, which regulates NFKB1, interferon, and STAT signaling pathways in cancer |