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FLASH GENE
Symbol TRIM8 contributors: mct/pgu - updated : 24-03-2021
HGNC name tripartite motif-containing 8
HGNC id 15579
DNA
TYPE functioning gene
STRUCTURE 13.83 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D10S1697 - D10S1267 - TRIM8 - D10S1692 - D10S1738 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 2753 61.4 551 - 2004 15345195
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestine   lowly
 liver   lowly
Nervousbrain    
Respiratorylung    
Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Nervousneuron Homo sapiens
Urinarypodocyte Homo sapiens
cell lineage
cell lines oligodendroglioma (anaplastic)
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING finger motif
  • two B-boxes (one type 1 and one type 2)
  • a coiled-coil domain (RBCC), the so called tripartite motif (TRIM) and a proline-rich C terminus
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Trim8 (97.3 pc)
    homolog to rattus Trim8 (97.8 pc)
    Homologene
    FAMILY
  • B box family, RBCC (tripartite motif (TRIM) family)
  • C-V TRIM family
  • RING family ubiquitin ligase
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    text
  • localizes at the mitotic spindle during mitosis and plays a role in centrosome separation at the beginning of mitosis with a subsequent delay of the mitotic progression and impact on chromosomal stability
  • basic FUNCTION
  • may be a regulator of SOCS-1 function
  • acting as a E3 ubiquitin ligase
  • modulates translocation of phosphorylated STAT3 into the nucleus through interaction with HSP90AB1 and consequently regulates transcription of NANOG in embryonic stem cells
  • positive regulator of TNF and interleukin-1beta (IL1B)–triggered NFKB activation
  • required for TNF- and IL1B–triggered NFKB activation and induction of inflammatory proteins
  • positively regulates TNF induced NFKB pathway
  • also enhanced the clonogenic and migration ability of cells by modulating NFKB
  • E3 ligase ubiquitously expressed in various cells, that is closely involved in innate immunity
  • TRIM8 regulates lysosomal biogenesis and autophagy flux
  • TRIM8 regulated autophagy is essential for its cytoprotective role during genotoxic stress induced cell death
  • is a novel regulator of DNA damage response (DDR)-autophagy crosstalk, which may play role in survival of cancer cells in presence of genotoxic agents
  • is required for virus-induced IFN response in plasmacytoid dendritic cells
  • TRIM8 encodes an E3 ubiquitin ligase involved in various pathological processes, including hypertrophy, antiviral defense, encephalopathy, and cancer development
  • tripartite E3 ubiquitin ligase, which regulates NFKB1, interferon, and STAT signaling pathways in cancer
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with SOCS1
  • interacts with protein inhibitor of activated STAT3 (PIAS3), which inhibits IL6-dependent activation of STAT3
  • interacted with MAP3K7, a serine/threonine kinase essential for TNF- and IL1B–induced NFKB activation
  • physically interacted with TP53, impairing its interaction with MDM2
  • its ubiquitin ligase activity is essential for regulation of NFKB activation in both cytoplasm as well as nucleus
  • TRIM8 plays a deleterious role in pressure overload-induced cardiac hypertrophy by accelerating the activation of MAP3K7-dependent signaling pathways
  • is a potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on MAP3K7
  • TRIM8 emerged as an essential regulator of IFN regulatory factor 7 (IRF7) function (PMID
  • TRIM8 interacts with KIFC1, and KIF11, two master regulators of mitotic spindle assembly and cytoskeleton reorganization
  • cell & other
    REGULATION
    induced by by interferon-gamma in epithelial and lymphoid cells
    LPS
    ASSOCIATED DISORDERS
    corresponding disease(s) NDSRNS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased expression in the livers of the steatohepatitis patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS