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FLASH GENE
Symbol ZNF638 contributors: mct - updated : 05-05-2012
HGNC name zinc finger protein 638
HGNC id 17894
DNA
TYPE functioning gene
STRUCTURE 103.30 kb     28 Exon(s)
MAPPING cloned Y linked N status provisional
regionally located in the PARK3 region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 6527 - 1978 - 2011 21602272
28 - 6517 - 1978 - 2011 21602272
- - 6842 - 1978 - 2011 21602272
- - 6463 - 1957 - 2011 21602272
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three domains of homology with the acidic nuclear protein matrin 3
  • the second motif being homolog to the RNA recognition motif
  • a C terminus DNA-binding domain
  • a serine/arginine rich sequence
  • multiple conserved motifs that may suggest that ZNF638 could function as an adaptor molecule to assemble other proteins in a functional transcription complex
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,coiled bodies (Cajal)
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • diffusing in cytoplasm during mitosis
  • dDuring adipocyte differentiation, ZNF638 is driven by its RS domain to localize in nuclear speckles
  • basic FUNCTION
  • binding double stranded DNA fragment by recognizing clusters of cytidines
  • novel and early regulator of adipogenesis that works as a transcription cofactor of CEBPs
  • CELLULAR PROCESS nucleotide, chromatin organization
    nucleotide, replication
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • physically interacts and transcriptionally cooperates with CCAAT/enhancer-binding protein (CEBPB and CEBPD)
  • induces PPARG expression through physical interaction and functional cooperation with CEBPs on the PPARG promoter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS