basic FUNCTION
| involved in endosomal protein sorting, acting as a receptor for neurotensin and as a clearance receptor on the cell surface |
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playing an essential role for NGFB-induced neuronal cell death |
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having distinct roles in pro-neurotrophin induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging |
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having physiological role as a death-inducing pathway in the central and peripheral nervous system |
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functioning as an alternative sorting receptor to the M6PR for these soluble hydrolases |
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acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF |
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essential, but also sufficient for biogenesis of GSVs and acquisition of insulin responsiveness in adipose cells |
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sortilin pathway has distinct roles in pro-neurotrophin-induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging |
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involved in development of the insulin-responsive glucose transport system in myocytes and directly involved in muscle differentiation via modulation of proNGF-p75NTR |
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regulator of neuronal viability and function through the regulation of both protein transport and signal transduction |
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binds apolipoproteins and potentially modulates lipoprotein metabolism, which might also affect neuronal function |
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important regulator of GRN levels |
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facilitates the signaling of all helical type 1 cytokines, which engage the IL6ST/LIF receptor complex |
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new function for sortilin as a modulator of BACE1 retrograde trafficking and subsequent generation of Abeta |
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transports BACE1 from the endosome to the TGN |
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plays a unique role in regulating BACE1-mediated cleavage of APP through regulating the subcellular distribution of BACE1 |
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SORT1 seems to play an important role in the development of cardiovascular disease and have functions beyond regulating LDL-cholesterol |
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is a key regulator of smooth muscle cell (SMC) calcification via its recruitment to extracellular vesicles |
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functions of SORT1 and SORCS2 during the establishment of neuronal structures and connections |
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SORT1 has been shown to act as a receptor, as a co-receptor and as an intra- and extracellular trafficking regulator |