basic FUNCTION
| may be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton |
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required for the maintenance of normal renal function |
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thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility |
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large intracellular proteins believed to link the extracellular matrix to the cytoskeleton via integrins |
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distinct differences in the cellular expression of TNS1, TENC1, and TNS3, suggesting that they may be able to function independently of each other in the kidney and the small intestine |
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is a focal adhesion molecule that links the actin cytoskeleton to integrins and forms signaling complexes through its multiple binding domains |
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is a key component of specialized cellular adhesions (fibrillar adhesions) that bind to extracellular fibronectin fibrils |
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plays an essential role in TGFB1-induced myofibroblast differentiation and myofibroblast-mediated formation of extracellular fibronectin and collagen matrix |