basic FUNCTION
| behaving in human embryonic kidney as an inositol phosphate and diacylglycerol-gated channel |
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suppressing epidermal growth factor-induced store-operated channel activation and growth in human corneal epithelial cells |
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implicated in the regulation of calcium homeostasis in astrocytes, particularly as part of a signaling complex that forms at junctional sites between astrocytes |
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necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin |
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NFAT signaling pathway |
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prominent cation channel in the vascular endothelium |
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potential key player in endothelial phenotype switching and tuning of cellular growth factor signaling |
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TRPC4 and TRPC5 are implicated in important physiological functions, such as growth cone guidance and smooth muscle contraction |
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both TRPC1 and TRPC4 are essential for an intrinsic membrane conductance mediating the plateau potential in lateral septal neurons, possibly as heteromeric channels |
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TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons |
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TRPC5 and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms |
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TRPC4 and TRPC5 proteins share 65p100 amino acid sequence identity and form Ca(2+)-permeable nonselective cation channels |
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contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons |