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FLASH GENE
Symbol ITPKC contributors: mct - updated : 09-02-2008
HGNC name inositol 1,4,5-trisphosphate 3-kinase C
HGNC id 14897
DNA
TYPE functioning gene
STRUCTURE 23.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3389 - 683 - Onouchi (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Endocrinepancreas   highly
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear import activity residing in its N-terminal domain and a nuclear export activity sensitive to treatment with leptomycin B
  • conserved catalytic domain of 275AA ATP binding site
  • six potential protein kinase C phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY inositol phosphokinase (IPK) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text nucleo-cytoplasmic shuttling
    basic FUNCTION
  • catalyzing the phosphorylation of Ins(1,4,5)P3 to Ins(1,3,4,5)P4, both of which are modulators of calcium homeostasis
  • acting as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway
  • playing a potential role as direct INSP3 metabolizing enzyme and direct regulator of Ca2+ responses to extracellular signals
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by by calmodulin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Kawasaki disease
    Variant & Polymorphism SNP a functional SNP (itpkc-3) significantly associated with Kawasaki disease susceptibility and also with an increased risk of coronary artery lesions in children
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS