SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
|
| intracellular,cytoplasm,organelle,membrane
|
| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic,vesicle
|
text
| late endosomes and and lysosomes colocalizing with VAMP8 |
|
actively cycles between endosomes and the plasma membrane |
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broadly located in the membranes of the three major cytoplasmic granules of human neutrophils, with a major location in azurophilic granules, which are mainly involved in phagocytosis |
|
STX7 colocalizes with RAB7A on late endosomes |
basic FUNCTION
| playing a role in vesicle trafficking between the Golgi complex and lysosomes |
|
syntaxin 7, syntaxin 8, VTI1B, and endobrevin/VAMP8 function in the fusion of late endosomes |
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may be involved in the intracellular vacuolation induced by Helicobacter pylori-produced cytotoxin VacA |
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regulates vesicle trafficking events involved in phagocytosis and cytokine secretion |
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regulates vesicle trafficking events in phagocytosis |
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might play a role in both exocytosis and phagocytosis in human neutrophils |
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is required for lytic granule release from cytotoxic T lymphocytes |