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FLASH GENE

Symbol

APOL3

contributors: mct - updated : 08-04-2011

HGNC name	apolipoprotein L, 3
HGNC id	14868

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	APOL1-APOL4 are clustered on human chromosome 22q13.1
STRUCTURE	25.85 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - APOL6 - APOL5 - APOL3 - APOL2 - APOL1 - qter
Authors	Page (01)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_145641 5 - 3632 42.7 388 - 2001 11374903 NM_145642 4 - 3793 40.1 363 - 2001 11374903 NM_145640 3 - 2123 44.3 402 - 2001 11374903

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain         Reproductive male system prostate     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta,liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conserved amphipathic alpha helices

HOMOLOGY

Homologene

FAMILY

APOL family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	may be affecting the movement of lipids in the cytoplasm or allow the binding of lipids to
	organelles.

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to prostate cancer (HPC)

Variant & Polymorphism SNP	rs2097365, rs2017329, rs2097465, having the strongest association with HPC risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS