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FLASH GENE
Symbol TAF7L contributors: mct - updated : 21-05-2017
HGNC name TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
HGNC id 11548
DNA
TYPE functioning gene
STRUCTURE 24.82 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 2371 - 462 - Akinloye (2007)
13 - 2203 - 376 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadiposewhite   Mus musculus
cells
SystemCellPubmedSpeciesStageRna symbol
not specificadipocyte Mus musculus
Reproductivegerm cell Homo sapiens
Reproductivespermatogonia Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Taf7l
intraspecies paralog to transcription factor TFIID subunit TAF7
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus
text
  • cytoplasmically localized in spermatogonia, and its expression becomes silenced at meiotic stages due to sex-chromosome inactivation
  • basic FUNCTION
  • acting as a TATA box binding protein-associated factor
  • may have an important function in spermatogenesis
  • is required for activating adipocyte-specific genes via a dual mechanism wherein it interacts with PPARG at enhancers and TBP/Pol II at core promoters (pMID: 23326641)
  • plays an integral role in adipocyte gene expression by targeting enhancers as a cofactor for PPARG and promoters as a component of the core transcriptional machinery (pMID: 23326641)
  • TAF7L and TERF2 may actually work together in regulating spermatogenesis
  • BNC1 might directly cooperate with TAF7L to regulate spermatogenesis
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the adipocyte-specific transcription factor PPARG during adipogenesis
  • TAF7L directly binds to gene promoters and that this binding is required for the expression of spermatogenic and metabolic genes in testis
  • interaction between a "nonprototypic" core promoter recognition factor (TERF2) and an orphan TAF subunit (TAF7L) in mammalian testis-specific gene transcription
  • cell & other
    REGULATION
    Other developmentally regulated during male germ-cell differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in cancer
    constitutional germinal mutation      
    have been found in human infertile patients with oligozoospermia
    tumoral     --low  
    in acute myeloid leukemia
    Susceptibility to spermatogenic failure
    Variant & Polymorphism other sequence variant in exon 13 may represent a risk factor for spermatogenic failure
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • histological analysis of testes revealed that Taf7l(-/Y) mice develop postmeiotic arrest at the first stage of spermiogenesis