basic FUNCTION
| alpha1,2-mannosidases activity |
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enhancing endoplasmic reticulum-associated degradation (ERAD) |
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is a regulator of blood triglyceride (TG) |
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EDEM3 provides a unique ERAD timing to misfolded glycoproteins, not only by its mannose trimming activity, but also by the positive and negative feedback modulated by the protease-associated and intrinsically disordered domain, respectively |
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involved in the endoplasmic reticulum-associated degradation pathway, responsible for the recognition of misfolded proteins that will be targeted and translocated to the cytosol and degraded by the proteasome |
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participates in mannose trimming from total glycoproteins |