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FLASH GENE
Symbol FBXL2 contributors: mct - updated : 27-03-2013
HGNC name F-box and leucine-rich repeat protein 2
HGNC id 13598
DNA
TYPE functioning gene
STRUCTURE 109.82 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3000 - 423 - 2000 10945468
14 - 2793 - 355 - 2000 10945468
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
endocrinebraindiencephalonpituitary  
Endocrinepancreas    
Nervousbrainforebraincerebral lobetemporal 
Reproductivemale systemtestis   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
cell cycle     cell cycle, checkpoint, G1S
Text placenta, lung, brain, kidney
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 40 AA F box motif
  • a F box domain
  • a CAAX motif (CVIL) (PMID;
  • twelve,leucine-rich repeats (LRR) at the C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • F box protein family
  • SCF (Skip-Cullin1-F-box protein) E3 ligase family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • phosphorylation dependent ubiquination
  • substrate recognition subunit of SCF ubiquitin protein ligase complex
  • geranylgeranylated cellular protein required for hepatitis C virus RNA replication (PMID;
  • impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation
  • implicated as an indispensible regulator of mitosis that serves as a tumor suppressor (
  • role for SCF (FBXL2) in regulating the fidelity of cellular division
  • ubiquitinates and destabilizes cyclin D2 protein leading to G(0) phase arrest and apoptosis in leukemic and B-lymphoblastoid cell lines
  • is a novel and dual regulator of APP metabolism through FBXL2-dependent ubiquitination of APP
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • one of the four subunits of the E3 ubiquitin protein ligase complex :(SCF) with SKP1, CUL1, RBX1, F-box protein bringing ubiquitin conjugating enzymes to substrates recruited by F-box
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • various target proteins
  • uniquely recognizes a canonical calmodulin (CALM1)-binding motif within CCND3 to facilitate its polyubiquitination
  • regulates amyloid precursor protein (APP) metabolism through APP ubiquitination
  • FBXO3 potently stimulates cytokine secretion from human inflammatory cells by mediating the degradation of the TRAF inhibitory protein, FBXL2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    antiproliferative effect of FBXL2 in lymphoproliferative malignancies
    ANIMAL & CELL MODELS