basic FUNCTION
| involved in a key S phase event and provide a link between the cell cycle machinery and activation of histone gene transcription |
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Cajal body-associated protein that is an essential downstream component of the cyclin E/Cdk2 signaling pathway and functions to coordinate multiple elements of the G1/S transition |
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playing a critical role in coordinated transcriptional activation of histone genes during the G(1)/S-phase transition and in S-phase entry |
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play an essential role in the transcriptional activation of histone genes at the G(1)/S-phase transition |
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recruits the TRRAP-KAT5 complex to histone gene promoters to coordinate the transcriptional activation of multiple histone genes during the G(1)/S-phase transition |
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CCND2 and the CDK substrate NPAT are required for self-renewal of human embryonic stem cells |
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essential for histone mRNA 3 prime end processing and recruits CDK9 to replication-dependent histone genes |
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implicated in nodular lymphocyte predominant Hodgkin lymphoma predisposition |
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is a crucial factor in regulating histone transcription and cell cycle progression |